Toxicity Versus Proximity : X-ray Crystallography,Nuclear Magnetic Spectroscopy, Infra red spectroscopy, Magnetic Susceptibility, CHN (Mass Analyzer)

ISBN-13: 9783846593493 / Angielski / Miękka / 2011 / 64 str.

Vaneet Dhir; Pooja Dhand

Opis

This approach was made by Dhir et al. based on X-ray Crystallography in terms of Toxicity versus Proximity on the basis of Ligand preparation and characterization by Nuclear Magnetic Spectroscopy, Infra red spectroscopy, Magnetic Susceptibility & CHN(Mass Analyzer) Techniques. DETP & DPTP have been found to be similar potential toxic as they have been used in fungicides and other antibacterial products. Approach has been made on the basis of Biomimetics. The study reveals that Cu complexes are much more potentially toxic than lead compounds because in lead compounds ligands may occupy all the centres or corners of the Pb(I/II)metal ions and very less void is left to interact physiochemically with various proteins/ amino acids or DNA of living cell to disrupt their cycle to become potential toxic and carcinogenic in nature. Thus Pb(I/II)metal ions are very toxic with less hydrophobic group while Cu(II) complexes are very toxic with big/steric ligands as compared to small one. This fact is strengthened on the basis of X-ray Crystal structure of one of the Copper (II) complexes.

O autorze

The Author did his Higher Secondary from B.V.M. School and completed his M.Sc (Honours School) from Panjab University, Chandigarh and also registered for Ph.D at G.N.D. University Amritsar- India. Author has Published 15 International Research Papers and written 04 International Books and 01 National Book & having 08 Years Teaching Experience.