Titanium Dioxide

ISBN-13: 9786206144168 / Angielski / Miękka / 136 str.

Madhava C. Reddy; Surendra Gulla; Dakshayani Lomada

Opis

This book describes the role of titanium dioxide nanotubes conjugated with quercetin in skin cancer and inflammation. TNT-Quercetin are human safe, cost effective and stable chemical with numerous biomedical applications. The authors of this book developed a novel drug combinational molecule by conjugating TNT with quercetin. The authors found the enhanced anti-cancer activity of TNT-Qu by inducing apoptosis and cell cycle arrest at the G2/M phase in B16F10 cells. Furthermore, TNT-Qu treatment up-regulated cleaved caspase-3 expression in B16F10 cells. More importantly, the in-vivo data demonstrated that TNT-Qu treatment inhibited the growth and metastasis of skin tumors significantly by down-regulating the pSTAT3 expression and restoring Gammad T cell population when compared to TNT or quercetin alone treatment. Taken together, the in-vitro and in-vivo data strongly suggest that TNT-Qu could be a novel combinational therapeutic agent for the treatment of skin cancer.

O autorze

Dr. Madhava C. Reddy is Associate Professor in Biotechnology and Bioinformatics at Yogi Vemana University. He has over 22 years of teaching and research experience in cancer biology, immunology, biotechnology. He published 50 research papers.