Tissue Type Plasminogen Activity: Volume I

ISBN-13: 9781315898216 / Angielski / Twarda / 2017 / 242 str.

Cornelius Kluft

Opis

This book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.

Spis treści

Section 1: Overviews/Introduction 1. The Tissue Plasminogen Activator � A Historical Account 2. Plasminogen Activators and Neoplasia 3. t-PA in Fibrin Dissolution and Hemostatis Section 2: Biochemistry 4. The Gene for t-PA, 5 Structure/Function Relationships of t-PA 6. Purification, Assay, and Standardizations of t-PA 7. Structure/Function Relationships of Human Plasminogen and Plasmin 8. Fibrinogen and Its Specific Sites for Modulation of t-PA Induced Fibrinolysis 9. Inhibitors of Plasminogen Activators 10. Control of t-PA Mediated Fibrinolysis

O autorze

Kluft, Cornelius