Tissue Repair and Fibrosis: The Role of the Myofibroblast

ISBN-13: 9783642636035 / Angielski / Miękka / 2012 / 224 str.

Alexis Desmouliere; Beatriz Tuchweber

Opis

Specialists from diverse disciplines discuss the important topics of Tissue Repair and Fibrosis. The Role of Myofibroblast. The Myofibroblast is implicated in many processes, such as tissue repair, fibrosis, and stromal reaction to tumors. This book seeks to provide an overview of the knowledge accumulated since this cell was first describes 25 years ago. Discussions focusses on three main topics: - Cellular and molecular biology of fibroblast and myofibroblasts - Wound healing: experimental models, and - Human fibrocontracted diseases.

Spis treści

Some Historical and Philosophical Reflections on the Myofibroblast Concept.- Transcriptional Regulation of the Desmin and SM22 Genes in Vascular Smooth Muscle Cells.- Modulation of Myofibroblast and Smooth-Muscle Phenotypes in the Lung.- Role of Platelet-Derived Growth Factors in Angiogenesis and Alveogenesis.- Transforming Growth Factor-? Gene Transfer to the Lung Induces Myofibroblast Presence and Pulmonary Fibrosis.- Transforming Growth Factor-? Induction of ?-Smooth Muscle Actin is Dependent on the Deformability of the Collagen Matrix.- Signal Transduction Pathways Activated During Fibroblast Contraction of Collagen Matrices.- Extracellular Matrix, Integrins and Focal Adhesions.- What Is New in Mechanical Properties of Tissue-Engineered Organs.- Fibroblast - Cytokine - Extracellular Matrix Interactions in Wound Repair.- Myofibroblastic Differentiation and Extracellular Matrix Deposition in Early Stages of Cholestatic Fibrosis in Rat Liver.- Gene Therapy of Wounds with Growth Factors.- What’s New in Human Wound-Healing Myofibroblasts?.- The Myofibroblast in Neoplasia.- The Concept of Organizing Pneumonia.- Endothelial Repair in Atherogenesis.- Glomerulosclerosis: The Role of Interstitial Myofibroblasts in its Progression.- The Myofibroblast as an Inflammatory Cell in Pulmonary Fibrosis.- Cell-Cell and Cell-Matrix Interactions During Breast Cancer Progression.- Hepatocyte Growth Factor Secreted by Human Liver Myofibroblasts Increases Invasiveness of Hepatocellular Carcinoma Cells.- Interplay of Matrix and Myofibroblasts During Hepatic Fibrogenesis.