Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems

ISBN-13: 9781461459651 / Angielski / Twarda / 2013 / 962 str.

Marc Thiriet

Opis

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Spis treści

Preface
Chapter 1: Blood
Chapter 2: Hematopoiesis
Chapter 3: Blood Cells
Chapter 4: Lymph Drainage
Chapter 5: Cardiomyocytes
Chapter 6: Heart Wall
Chapter 7: Vessel Wall
Chapter 8: Smooth Myocytes
Chapter 9: Vascular Endothelium
Chapter 10: Vascular Growth
Chapter 11: Tissue Development, Repair, and Remodeling
Chapter 12: Airway Surface Liquid and Respiratory Mucus
Chapter 13: Surfactant
Chapter 14: Conclusion
References
List of Currently Used Prefixes and Suffixes
List of Aliases
Complementary Lists of Notations
Index

Blurb

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models.  The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.

Reviews structure and function of major constituents of the circulatory and respiratory apparatus

Describes major cellular processes involved in signaling, interactions, and adaptive responses of physiological conduits

Integrates biology, chemistry, and physics for the multidisciplinary exploration and modeling of physiological flows

Focuses on mechanotransduction-induced regulation