Tissue Engineering

ISBN-13: 9780124201453 / Angielski / Twarda / 2014 / 896 str.

Blitterswijk, Clemens Van De Boer, Jan

Opis

Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface.

• Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion
• Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning
• New edition contains material on regulatory authorities and commercial considerations in tissue engineering

Spis treści

1. Introduction2. Stem cells3. Tissue morphogenesis and homeostasis4. Cellular signaling5. ECM6. Biomaterial chemistry7. Microfabrication8. Materiomics: high throughput screening, data analysis and modeling9. Scaffold design and fabrication10. Controlled release11. Monitoring & control - towards processing - manufacturing12. Cell sourcing/Cell culture/ Cell differentiation/cryopreservation13. In vivo engraftment and functionality (prevascularization, functionalization of TE grafts)14. The biomaterial/tissue interface15. Skin 16. Muskuloskeletal17. Tissue Engineering of the nervous system18. Cardiovascular19. Organs20. Tissue and organs on a chip21. Clinical translation22. The product: Quality contro aspects/GMP-GCP production aspects23. Ethical issues

O autorze

Clemens van Blitterswijk graduated as cell biologist from Leiden University in 1982, defending his PhD thesis in 1985 at the same university. Today his research focuses on tissue engineering and regenerative medicine, forming a unique basis of multidisciplinary research between materials and life sciences. Van Blitterswijk has authored and co-authored more than 380 peer reviewed papers (H index 90, Scopus); is one of the most frequently cited Dutch scientists in TE; the applicant and co-applicant of over 100 patents; has guided 50 PhD candidates through their thesis as supervisor or co-supervisor and currently has 30 PhD candidates under his supervision. Dr. van Blitterswijk received a number of prestigious international awards including the George Winter award of the European society for Biomaterials, the Career Achievement Award of the Tissue Engineering and Regenerative Medicine International Society and is a member of the KNAW (The Royal Netherlands Academy of Arts and Sciences). Jan de Boer is an experienced University Professor and Chief Scientific Officer with a demonstrated history of working in academia and biotech. As a research professional he is skilled in Stem Cells, Biomaterial Engineering and Regenerative Medicine. Jan is interested in the molecular complexity of cells and how molecular circuits are involved in cell and tissue function. With a background in mouse and Drosophila genetics, he entered the field of biomedical engineering in 2002 and has since focused on understanding and implementing molecular biology in the field of tissue engineering and regenerative medicine. His research is characterized by a holistic approach to both discovery and application, aiming at combining high throughput technologies, computational modeling and experimental cell biology, to streamline the wealth of biological knowledge to real clinical applications.