Thyroid Systems Engineering: A Primer in Mathematical Modeling of the Hypothalamus-Pituitary-Thyroid Axis

ISBN-13: 9788793609594 / Angielski / Twarda / 2018 / 300 str.

Simon Goede; Melvin Khee Leow

Opis

Targets an optimal treatment of people suffering from thyroid hormone disorders. The content is motivated by in-depth observations of such patients whose rich data supported the theoretical framework arising from formal mathematical reasoning, guided by the nature of thyroid physiology.

Spis treści

• Preface;
• 1. General Introduction;
• 2. The Physiology of the HPT Axis;
• 3. Modeling Principles;
• 4. Statistics in Research: Critical Comments on Statistical and Scientific Methods;
• 5. Introduction to Systems Theory;
• 6. Hypothalamus-Pituitary Relationship between [FT4] and [TSH];
• 7. The Thyroid Gland and the Relationship between [TSH] and [FT4];
• 8. Maximum Curvature of the HP and Thyroid Characteristic;
• 9. The Hypothalamus-Pituitary-Thyroid Control System;
• 10. Reference Ranges;
• 11. Extrapolation to the Set Point from a Single Available Measurement;
• 12. Measurement Methods and Error Interpretation of [FT4] and [TSH];
• 13. Model Identification, Validation and Outlier Selection;
• 14. T4 and T3 Half-Life and Appearance Dynamics;
• 15. Liothyronine (T3) and Levothyroxine (T4) Pharmacokinetics;
• 16. Circadian Feedback Dynamics and Set Point Stability Analysis of the Hypothalamus Pituitary Thyroid System;
• 17. HPT Simulation;
• Computer Software to Calculate the Set Point: Thyroid-SPOT ;
• Keyword Index.

O autorze

Simon Goede, Melvin Khee-Shing Leow