Thermostable Proteins: Structural Stability and Design

ISBN-13: 9781439839133 / Angielski / Twarda / 2011 / 188 str.

Srikanta Sen; Lennart Nilsson

Opis

This text covers the basic structural, thermodynamic and kinetic principles are covered and molecular strategies for the adaptation to high temperatures revealed by structure analysis are delineated. The roles of fluctuations, hydration and internal packing are thoroughly dicussed.

Spis treści

Delineation of the Conformational Thermostability of Hyperthermophilic Proteins Based on Structural and Biophysical Analyses. Role of Packing, Hydration, and Fluctuations on Thermostability. Analyzing Protein Rigidity for Understanding and Improving Thermal Adaptation. Thermostable Subtilases (Subtilisin-Like Serine Proteinases). Combined Computational and Experimental Approaches to Sequence-Based Design of Protein Thermal Stability. Designing Thermophilic Proteins: A Structure-Based Computational Approach. Index.