1. Prostate Gland Anatomy and Hormonal Factors Contributing to Cancer Development 2. Pathophysiology and Molecular Aberrations of Castration Resistant Prostate Cancer 3. Role of Tumor Microenvironment in Prostate Cancer Therapy Resistance 4. Androgen Receptor-Dependent Mechanisms Mediating Therapy Resistance in Prostate Cancer 5. Epigenetic Changes Driving Therapy Resistance in Prostate Cancer 6. Role of Cancer Stem Cells in Prostate Cancer Therapy Resistance 7. Resistance to Taxane Chemotherapies in Prostate Cancer 8. Resistance of Prostate Cancer to Topoisomerase Inhibitors 9. Resistance of Prostate Cancer to Kinase Inhibitors 10. Radioresistance Mechanisms in Prostate Cancer 11. Immunotherapeutic Strategies and Immunotherapy Resistance in Prostate Cancer 12. Overcoming Resistance in Prostate Cancer with Targeted and Small Molecule-Based Therapies 13. Novel Treatment Strategies to Overcome Resistance in Prostate Cancer