Therapeutic Uses of Botulinum Toxin

ISBN-13: 9781617378423 / Angielski / Miękka / 2011 / 238 str.

Grant C. Cooper

Opis

Justinius Kerner, a German medical officer and poet, was the first to realize that botulinum toxin potentially might be useful for therapeutic purposes. Kerner made this observation in 1822, but he did not call the toxin botulinum toxin. Instead, Kerner called it the substance in wirkenden stoffes, which translates to bad sausages. Kerner realized that there was a fat poison or fatty acid within sausages that produced the toxic effects that we now know as botulism. Nearly a century would pass before the bacterium producing the toxin would be isolated and the toxin ultimately renamed botulinum toxin. As farsighted as Kerner was, it is doubtful that even he could have predicted just how much potential therapeutic punch was packed within his wirkenden stoffes. It was not until 1978, more than a century and a half after Kerner s prediction, that Dr. Allan Scott received Food and Drug Administration approval to test botulinum toxin type A in human volunteers. We do not yet have a comprehensive understanding of precisely how botulinum toxin works in the human body or how our bodies fully respond to the toxin. We do know that it temporarily paralyzes muscle by inhibiting the release of acetylcholine, and it also appears to inhibit the release of other neurotransmitters."

Recenzje

From the reviews:

"This book presents many of the clinical uses of the relatively new drug, botulinum toxin. ... the book attempts to cover nearly all uses of the medication known to the assorted authors, including potential treatments for which there is little peer-reviewed literature. The purpose is to provide an overview of this medication, and present clinical scenarios in which the drug might be an appropriate choice. ... The target audience should be clinicians (physicians and therapists) ... ." (Ross Bogey, Doody's Review Service, January, 2008)

Spis treści

TOC Chapter 1: History and Mechanism of Action Zinovy Meyler, DO, Grant Cooper, MD Chapter 2: Spasticity Elise Weiss, MD, David Lin, MD Chapter 3: Radiation Fibrosis Syndrome Applications - Trismus, Trigeminal Neuralagia, and Cervical Dystonia Michael Stubblefield, MD Chapter 4: Back Pain Rebecca Brown, MD*, Avniel Klein MD*, Alex Visco, MD, Joseph E. Herrera, DO *These authors contributed equally and are co-first authors. Note to Humana -- If this is ever done, do this. Otherwise, just make Rebecca the first author. Thanks. Chapter 5: Piriformis Syndrome Loren M. Fishman, MD, Alena Polesin, MD, Steven Sampson, DO Chapter 6: Plantar Fasciitis Mary S. Babcock DO Chapter 7: Headache Jerome S. Schwartz, MD, Phillip Song, MD, Andrew Blitzer, MD, DDS Chapter 8: Spasmodic Dysphonia Jerome S. Schwartz, MD, Phillip Song, MD, Andrew Blitzer, MD, DDS Chapter 9: Sialorrhea and Frey's Syndrome. Phillip C. Song, MD, Jerome Schwartz, MD, and Andrew Blitzer, MD. DDS. Chapter 10: Cosmetic Applications Tara D. Miller, MD, Isaac M. Neuhaus, MD Chapter 11: Hyperhidrosis Joely Kaufman, MD, FAAD, Leslie Baumann, MD, FAAD Chapter 12: Urologic Applications David E. Rapp, MD, Gregory T. Bales, MD Chapter 13: Gastrointestinal Applications: Achalasia, Gastroparesis, and Anal Fissure Shayan Irani, MD, Frank Friedenberg, MD Chapter 14: Blepharospasm Amir Cohen, MD, MBA, Marc J. Spirn, MD, David Khoramian, BA, and C. Robert Bernardino MD Chapter 15: Economics, Immunity, and Future Directions Victoria Chan Harrison, MD, David Lin, MD

Blurb

Therapeutic Uses of Botulinum Toxin outlines and examines our current understanding of botulinum toxin and its various therapeutic applications. The editors explore how this novel compound fits into a wide variety of treatment algorithms across medical subspecialties. Each chapter focuses on a particular symptom and explains how botulinum toxin is currently used for treatment. The chapter authors are all leaders in their fields and are respected for their progressive approach to treatment. Physicians will benefit not only from those chapters devoted to their particular sub-specialty, but from the inspiring success resulting from the use of botulinum toxin in other patient populations. The concluding chapter examines questions of immunity, explores economic issues, and attempts to forecast future directions for this novel and somewhat mysterious drug. Clinicians across a wide variety of disciplines will refer to this comprehensive reference time and time again.