Therapeutic Immunosuppression

ISBN-13: 9780792368892 / Angielski / Twarda / 2001 / 512 str.

Angus W. Thomson; A. W. Thomson

Opis

This work has broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (for example, rheumatoid arthritis), skin disease and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential. There is also considerable interest in the potential of cell-based therapies (particularly hematopoietic stem and dendritic cell therapy) of allo- and autoimmunity. Important recent advances in the immunotherapy of allergic diseases are also covered in this book. This volume is intended both for practising physicians and surgeons and for biomedical scientists at the graduate/postdoctoral levels, and is designed to provide the theory behind these various approaches to immunosuppression, and to provide state-of-the-art reviews of current developments in each area.

Spis treści

1. Calcineurin-targeted inhibition of immune reactivity; L. Kung, P.F. Halloran. 2. Experimental immunosuppressive agents; J. Klupp, R. Morris. 3. Polyclonal and monoclonal antibodies; L. Chatenoud. 4. Cytokines and their receptors as therapeutic targets; P. Nickerson. 5. Novel strategies using MHC peptides; C.C. Magee, M.H. Sayegh. 6. Costimulatory blockade as a therapeutic regimen for prolonging allograft survival and inducing tolerance: an overview of recent research; M.M. Hamawy, et al. 7. Oral tolerance; H.L. Weiner. 8. Hematopoietic stem cell chimerism and tolerance induction; H. Shirwan, S.T. Ildstad. 9. Strategies to promote tolerance induction using dendritic cells; A.W. Thomson, L. Lu. 10. Gene therapy for autoimmune disease and transplantation; C.H. Evans, et al. 11. Local immunosuppression: the eye; J.W. Streilein, A.W. Taylor. 12. Topical skin immune system response modifiers; J.D. Bos. 13. Local immunosuppression: the lung; A.T. Iacono, et al. 14. Therapy of autoimmune connective tissue diseases; T.M. Wright, D.P. Ascherman. 15. Immunotherapy for allergic diseases; D. Umetsu, R.H. DeKruyff. 16. Therapeutic strategies for xenotransplantation; J.L. Platt. 17. Medical complications of immunosuppression; J. McCauley, R. Shapiro. 18. Neurological complications of immunosuppression; B.H. Eidelman, R. Shapiro. 19. Infectious complications of immunosuppression; S. Kusne, R. Shapiro. Index.