Theranostics, Gallium-68, and Other Radionuclides: A Pathway to Personalized Diagnosis and Treatment

ISBN-13: 9783642279935 / Angielski / Twarda / 2012 / 578 str.

Richard P. Baum; Frank R. Sch

Opis

This book is based on contributions presented at the 1st World Congress on Gallium-68 and Peptide Receptor Radionuclide Therapy, which examined recent developments in theranostics - the emerging field of molecular targeting of vectors that can be used for both diagnosis and therapy, when modified accordingly. The focus of this book is on the rapidly developing research into and clinical applications of gallium-68 and other generator-produced PET radionuclides in the personalized diagnosis and treatment of neuroendocrine tumors and other diseases. In addition, new PET radiopharmaceuticals are considered, and the latest ideas and concepts, presented. Theranostics embodies both molecular and personalized medicine. It is at the cutting edge of medicine, and the contents of this volume will be of interest to chemists, physicians, and investigators dealing with generators, PET radiochemistry, molecular imaging, and radionuclide therapy.

Recenzje

From the reviews:

"The general themes of this book (theranostics and peptide receptor-targeted radiotherapy) derive from evolving successes in the use of generator-produced ⁶⁸Ga for molecular imaging of disease. ... This book is an excellent resource for investigators interested in gaining a detailed understanding of the state of the art in ⁶⁸Ga and peptide receptor radionuclide therapy-based theranostics for preclinical and emerging clinical applications." (Michael K. Schultz, The Journal of Nuclear Medicine, Vol. 54 (4), April, 2013)

Spis treści

From the contents: Ge-68/Ga-68 generators.- Automation strategies in Ga-68 radiopharmaceutical preparations.- Post-processing via cation exchange cartridges.- Gallium-68 generator integrated system: elution – purification - concentration integration.- Purification and labelling strategies for ⁶⁸Ga from ⁶⁸Ge/⁶⁸Ga generator eluate.- ⁶⁷Ga and ⁶⁸Ga purification studies.- The diversity of [⁶⁸Ga]Ga-based imaging agents.- Nanoparticles and phage display selected peptides for imaging and therapy of cancer.- “Click” cyclized gallium-68 labeled peptides for molecular imaging and therapy: Synthesis and preliminary in vitro and in vivo evaluation in a melanoma model system.- Early experience with ⁶⁸Ga-DOTATATE preparation .- ⁶⁸Ga-radiopharmaceuticals for PET imaging of infection and inflammation.- ⁶⁸Ga-labeled bombesin analogs for receptor mediated imaging.- A novel ⁶⁸Ga-labelled pteroic acid-based PET tracer for tumour imaging via the folate receptor.- Measurement of protein synthesis: In vitro comparison of ⁶⁸Ga-DOTA-puromycin, [³H]tyrosine and 2-fluoro-[³H]tyrosine.- Hypoxia imaging agents labeled with positron emitters.- Lu-177/Y-90 intermediate affinity monoclonal antibodies targeting EGFR and HER2/c-neu: preparation and preclinical evaluation.- Divergent role of ⁶⁸Ga labeled somatostatin analogs in the work-up of patients with NETs.- Differential uptake of ⁶⁸Ga-DOTATOC and ⁶⁸Ga-DOTATATE in PET/CT of gastroenteropancreatic neuroendocrine tumours.