The effects of erythropoietin on telomerase in malignant cells

ISBN-13: 9783659515828 / Angielski / Miękka / 2014 / 52 str.

Uziel Orit;Kanfer Gil;Lahav Meir

Opis

The study described in this book presents the effects of erythropoietin on Telomerase activity and regulation in malignant and non- malignant non-erythroid cells. Erythropoietins exposure upregulates telomerase activity in a post translational level by the Lyn/SRC AKT axis. Inhibition of telomerase that shortens telomeres abolished that effect, suggesting that erythropoietins treatment might be given with anti- telomerase compounds to minimize the upregulation of telomerase in the cancer cells.

O autorze

Orit Uziel got her Ph.D degree from the Tel Aviv University, Israel at 2000. Since then she is running the Laboratory for Telomere Research together with prof. Lahav and Prof. Nordenberg at the Felsenstein Medical Research Center, Rabin Medical Center and Tel Aviv University. The main focus of her laboratory is translational research.