The Zebrafish: Disease Models and Chemical Screens: Volume 105

ISBN-13: 9780123813206 / Angielski / Twarda / 2011 / 616 str.

III H. William Detrich

Opis

This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish.

• Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls
• This volume concentrates on Disease Models and Chemical Screens

Spis treści

Part I: Disease Models 1. Germ Cell Tumors in Zebrafish 2. Schwann Cell Myelination Mutants as Models of Multiple Sclerosis 3. In Vivo Analysis of Zebrafish Adipogenesis 4. Host-Microbe Interactions in the Zebrafish 5. Hematopoietic Stem Cell Development and Blood Flow 6. Zebrafish as a Model for Hemorrhagic Stroke 7. Zebrafish Adaptive Immunity: Structure and Function of Physiologic Development and Malignant Transformation 8. Zebrafish VHL Disease Model 9. Muscle Diseases 10. Basement Membrane Diseases 11. Lymphangiogenesi 12. Osteogenesis 13. Zebrafish Assays of Ciliopathies 14. Infectious Disease: Innate Immunity 15. Tuberculosis 16. Cancer 17. Melanoma 18. Pancreatic Cancer 19. Rhabdomyosarcoma 20. Transplantation in Zebrafish 21. Modeling Human Disease by Gene Targeting 22. Fluorescent Imaging of Cancer 23. Zebrafish as a Model for Fanconi's Anemia

Part II: Chemical Screens 24. Chemical Screens for Potential Therapeutics 25. Psychotropic Drug Discovery by Automated Behavioral Phenotyping 26. Discovery and Use of Small Molecules for Probing Biological Processes