The Thrombotic Process in Atherogenesis

ISBN-13: 9781468477894 / Angielski / Miękka / 2012 / 546 str.

Opis

Two infonnal meetings of consultants expert in hemostatic phenomena and in atherogenesis were held in Bethesda, Maryland, in December 1975 and February 1976 by the National Heart, Lung, and Blood Institute. Their purpose was to discuss the current status of knowledge concerning the thrombotic process in the pathogenesis of atherosclerosis. It was readily agreed that thrombosis often played a major role in plaque building and in plaque complication. It was also commented, however, that the data were qualitative in nature and that quantitative infonnation was remarkably sparse. The term thromboatherogenesis was thought to be appropriate for those phenomena in which the full expression of the thrombotic process is manifest. At the same time, recent research was noted in which what appears to be an important pathway for the initiation of atherogenesis arises from the reaction of platelets with injured arterial endothelium and'Subendothelium without necessarily involving the complete classical thrombotic process. A name was not coined for this circumstance, but it was held that thromboatherogenesis was not a fully appropriate one.

Spis treści

First Plenary Session Conceptual Aspects.- Atherogenesis: The Process from Normal to Lesion.- The Geographic Pathology and Topography of Atherosclerosis and Risk Factors for Atherosclerotic Lesions.- Light and Electron Microscopy of Human Atherosclerotic Lesions.- The Plasma Lipoproteins: Current Concepts of Metabolism and Structure with Clinical Implications.- Progression and Regression of Atherosclerotic Lesions.- Clinical and Pathological-Aspects of Arterial Thrombosis and Thromboembolism.- Platelets, Thrombosis and Atherosclerosis.- Thrombosis and Atherosclerosis.- Endothelium 1977: A Review.- Atherosclerosis and Inflammation.- Discussion Following First Plenary Session.- First Workshop Session Interaction of Platelets and Coagulation with the Arterial Wall.- Summary of Workshop 1a: Endothelium.- Discussion Following Workshop 1a.- Summary of Workshop 1b: Smooth Muscle.- Discussion Following Workshop lb.- Second Plenary Session Risk Factors for Atherosclerosis and Thrombosis.- Risk Factors for Atherosclerosis.- Relationship of Risk Factors for Atherosclerosis to Arterial Thrombosis.- Possible Effects of Risk Factors on Fibrinolysis.- Hypercholesterolemia and Platelets.- Pilot Epidemiological Studies in Thrombosis.- Discussion Following Second Plenary Session.- Second Workshop Session Lipid-Membrane Interactions of Platelets, Coagulation, and the Arterial Wall at the Molecular Level.- Summary of Workshop 2a: Lipid-Membrane Interactions of Platelets and Coagulation.- Discussion Following Workshop 2a.- Summary of Workshop 2b: Lipid-Membrane Interactions of Platelets and Coagulation with the Arterial Wall.- Discussion Following Workshop 2b.- Third Workshop Session the Thrombotic Process and Atherogenesis in Specific Arterial Injury.- Summary of Workshop 3a: Hemodynamic Injury.- Discussion Following Workshop 3a.- Summary of Workshop 3b: Immunologic Injury.- Discussion Following Workshop 3b.- Fourth Workshop Session Animal Models of Atherosclerosis Involving the Thrombotic Process.- Summary of Workshops 4a & 4b: Animal Models of Atherosclerosis Involving the Thrombotic Process.- Discussion Following Workshops 4a & 4b.- Atherothrombology.- Third Plenary Session Clinical Assessment of the Thrombotic Process in Relation to Atherosclerosis.- Platelet Function in Thrombosis and Atherosclerosis.- Platelet Survival Determination in Atherosclerosis.- Assays for Hypercoagulability.- Assay of Fibrinopeptides A and B and of Released Platelet Proteins as a Measure of Activation of Hemostasis.- Discussion Following Third Plenary Session.- Epilogue.- Appendix A Endothelium 1977: A Review (Bibliography).- Appendix B Workshop Participants.- Author Index.