The Statistical Evaluation of Medical Tests for Classification and Prediction

ISBN-13: 9780198565826 / Angielski / Miękka / 2004 / 318 str.

Margaret Sullivan Pepe

Opis

This book describes statistical concepts and techniques for evaluating medical diagnostic tests and biomarkers for detecting disease. More generally, the techniques pertain to the statistical classification problem for predicting a dichotomous outcome. Measures for quantifying test accuracy are described including sensitivity, specificity, predictive values, diagnostic likelihood ratios and the Receiver Operating Characteristic Curve that is commonly used for continuous and ordinal valued tests. Statistical procedures are presented for estimating and comparing them. Regression frameworks for assessing factors that influence test accuracy and for comparing tests while adjusting for such factors are presented. This book presents many worked examples of real data and should be of interest to practicing statisticians or quantitative researchers involved in the development of tests for classification or prediction in medicine.

Recenzje

I very much recommend this book to a range of audiences, from those wanting an introduction to diagnostic test concepts and methods to active researchers in the area. This book is likely to stimulate considerable progress in development of new statistical methods for diagnostic tests, an area that relative to therapeutics has received little attention from biostatisticians.