Part I. The Osteochondral System: 1. General principles relating to the joint tissues and their function; 2. The osteochondral junction; 3. Failure of the osteochondral junction; 4. Shear failure of the osteochondral junction; 5. A large in vivo model exploring extreme physiological loading of the osteochondral tissues; Part II. The Intervertebral Disc-Endplate System: 6. Relevant anatomy and macro-level structure; 7. The elastic fibre component in the disc; 8. Detailed analysis of the disc-endplate system; 9. Structure of the nucleus and its relation to annulus and endplate; 10. Experimental investigation of failure of the annulus-endplate junction region; 11. Endplate involvement in whole disc failure; 12. Micromechanics of failure of the disc-endplate system under realistic loading; Part III. The Enthesis: 13. Tendon and ligament biomechanics; 14. The enthesis: composition, structure and function; 15. Exploring enthesis structure-function relationships; 16. Managing the modulus mismatch.