The Secret Lives of Transcription Factors: In Heterochromatin Regulation

ISBN-13: 9783031290275 / Angielski

Willis X. Li; Louise Silver-Morse

Opis

This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors  GAGA, HP1, Rb, STAT, ATF-2 and NF-kB.  Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage.  Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject.  It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.

Spis treści

Chapter 1 Introduction

Chapter 2 Unconventional functions of transcription factors

GAGA transcription factor

Heterochromatin protein 1

Retinoblastoma protein

STAT

ATF-2

NF-kB

Chapter 3 STAT and HP1, in their unconventional roles, promote longevity and protect against DNA damage and cancer

STAT and HP1 promote longevity

STAT and HP1 protect against DNA damage

Increased levels of STAT and HP1 hinder carcinogenesis in a mouse xenograft model

Chapter 4 The possible biological significance of transcription factors’ unconventional functions

The epigenome

Processes in the cell nucleus

Future Work

O autorze

Dr. Willis X. Li received his Ph.D. from Columbia University and is currently Professor of Medicine in the Biomedical Sciences Graduate Program at the University of California, San Diego. He is a prolific author and his more recent works include two books for Springer's Methods in Molecular Biology/Protocols series. His investigative interests are JAK/STAT signaling and innate immunity, epigenetic mechanism of tumor suppression and tumorigenesis, and the role of heterochromatin in aging and stem cells.

Dr. Louis Silver-Morse received her Ph.D. from the State University of New York at Stony Brook.  She did research in genetics as a postdoctoral fellow in the Department of Biomedical Genetics at the University of Rochester Medical Center.  She has published research articles and reviews in premier scientific journals.  She is currently a freelance writer/editor.