The Role of Regulatory T Cells in Multiple Myeloma

ISBN-13: 9783659597381 / Angielski / Miękka / 2014 / 96 str.

Ercetin Ayse Pinar;Ozcan Mehmet Ali;Aktas Safiye

Opis

Multiple myeloma is a hematological cancer which is characterized by malign proliferation of plasma cells and their precursors. Although myeloma cells express antigens which can be recognized by host T cells they can be rarely eradicated by the immune system because of the immunsupression by tumor microenvironment. The immunsuppressive regulatory T cells (Treg) with CD4+ CD25+ Foxp3+ fenotype are increased in peripheral blood of multiple myeloma patients which have key roles on oto-immune control, T-cell homeostasis, immunmodulation of all the immune response. This book is a combination of Master of Science and PhD dissertations examining the role of Treg cells in multiple myeloma. The interaction of Treg cells with autologous peripheral blood stem cell transplantation and bortezomib treatment is evaluated by ex vivo and in vitro tests. The findings point out the importance of Treg cells in multiple myeloma and the experimental design will help the researchers interested in the same field.

O autorze

She was born in May 8, 1985 in Izmir, Turkey. She had her Bachelor degree in the field of Biochemisty from Ege University in 2007. She received her Master of Science and PhD degrees in the field of Basic Oncology from Izmir Dokuz Eylul University in 2010 and 2014 respectively. She still works as a Research Assistant in Izmir Dokuz Eylul University.