The Role of Pendrin in Health and Disease: Molecular and Functional Aspects of the Slc26a4 Anion Exchanger

ISBN-13: 9783319432854 / Angielski / Twarda / 2017 / 226 str.

Markus Paulmichl; Silvia Dossena

Opis

This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health.
Pendrin is a membrane transport protein expressed in the thyroid, inner ear, kidney and airways, and was recently found in a variety of other tissues and organs. Pendrin malfunction may cause a genetic disease called Pendred syndrome or non-syndromic deafness.
The book provides a thorough description of the multifaceted role of pendrin in human health and disease. As such, it offers an invaluable tool for physiology and pathology researchers, while also providing essential guidance for otorhinolaryngologists and endocrinologists in the diagnosis of Pendred syndrome and pendrin-related deafness.

Recenzje

"The purpose is to summarize the current knowledge about the role of pendrin in normal physiology and disease pathology. The intended audience is predominantly researchers and physicians interested in a detailed description of the multifaceted function of pendrin. However, the book also could serve as a good source for undergraduate and graduate students and postgraduate trainees interested in thyroid physiology and pathology as well as physiology, pathology, and diagnosis of deafness in general." (Partha Kasturi, Doody's Book Reviews, June, 2017)

Spis treści

Pendrin and the Pendrin Consortium.- Pendrin role in the inner ear.- Pendrin role in the thyroid and Pendred syndrome.- Pendrin role in the kidney and hypertension.- Interplay between Pendrin and other renal transport molecules.- Pendrin role in the airways: links with asthma and COPD.- Pendrin expression and function in non-conventional sites.- Transcriptional regulation and epigenetics of Pendrin.- Models for Pendrin structure.- Genetic diagnosis of deafness.- Functional and molecular properties of Pendrin allelic variants.- Potential pharmacological interventions for Pendrin dysfunction.

O autorze

Prof. Dr. Markus Paulmichl Institute of Pharmacology and Toxicology of the Paracelsus Medical University Salzburg, Austria

Silvia Dossena, PhD Institute of Pharmacology and Toxicology of the Paracelsus Medical University Salzburg, Austria