The Role Of Fibronectin-III1 In The Regulation Of Inflammatory Pathway

ISBN-13: 9783845441948 / Angielski / Miękka / 204 str.

Ran You

Opis

This book provides potential novel targets for therapies of human cancer and inflammatory diseases. The studies in this book have revealed the cryptic activity within the FnIII-1 module modulates the tissue inflammatory response and suggests that fibronectin (Fn) matrix remodeling can induce the expression of cytokines by stromal cells present in the tissue microenvironment, providing evidence for a previously unrecognized link between fibronectin matrix remodeling and the regulation of the innate immune system. These studies have dissected FnIII-1c's effects on fibronectin matrix from its effects on the activation of intracellular signaling, elucidated the mechanism by which unfolding of fibronectin Type III-1 domain regulates inflammatory response in tissue microenvironment and clarified how local mechanical properties within tissue microenvironment may protect tumor cells from therapeutic treatment.

O autorze

Dr. You received her B.S. at School of Life Science, Beijing Normal University in Beijing, China in 2001. In 2006, She received a M.S. degree at Rensselaer Polytechnic Institute in Troy, NY. She received her PhD in Biological Science at the Center for Cell Biology and Cancer Research of Albany Medical College in Albany, NY in 2011.