The Rights and Wrongs of Zebrafish: Behavioral Phenotyping of Zebrafish

ISBN-13: 9783319337739 / Angielski / Twarda / 2017 / 327 str.

Laporte Allan V. Kalueff

Opis

Animal models and tests have become increasingly important for biomedical research, enabling a better understanding of pathogenic pathways involved in various human disorders. Over the last decades, zebrafish (Danio rerio) have become a very popular model organism in biomedical research. Recently, this fish has entered the waters of neuroscience and biological psychiatry, quickly becoming an indispensable model species in this field. With a high genetic homology to humans ( 75% based on coding regions), it is not surprising that humans and fish are very similar physiologically (and behaviorally).
Therefore, it should not come as a surprise that zebrafish can be an excellent model of human neuropsychiatric disorders. While some classical psychiatrists may not too easily be persuaded by this generalization, the current book "The rights and wrongs of zebrafish: principles of behavioral phenotyping and CNS disease modeling" explains, in a domain-by-domain manner, how exactly zebrafish models can be used to target a wide range of human brain disorders and aberrant phenotypes.
The contributors to this book are leading international scholars whose work spearheads innovative zebrafish neuroscience research around the world. Written by top experts in the field, this book makes for a useful, balanced and up-to-date reading that outlines the use of zebrafish to study the pathological mechanisms underlying neuropsychiatric disorders.

Spis treści

Preface

Chapter 1. Mutagenesis and transgenesis in zebrafish. Fabienne E. Poulain

Chapter 2. Developing zebrafish depression-related models. Julian Pittman and Angelo Piato

Chapter 3. Zebrafish models of anxiety-like behavior. Adam D. Collier, Allan V. Kalueff  and David J. Echevarria

Chapter 4. Assessing cognitive phenotypes in zebrafish. David J. Echevarria, Adam D. Collier and Elizabeth A. Lamb

Chapter 5. Social phenotypes in zebrafish, Rita Nunes, Nathan Ruhl, Svante Winberg and Rui F. Oliveira 

Chapter 6. Modeling OCD endophenotypes in zebrafish. Matthew Parker

Chapter 7. Zebrafish models of attention-deficit/hyperactivity disorder (ADHD). William Norton, Merlin Lange, Laure Bally-Cuif and Klaus-Peter Lesch

Chapter 8. Zebrafish neurotoxicity models. Julian Pittman    

Chapter 9. Sleep phenotypes in zebrafish. David J. Echevarria and Kanza M. Khan

Chapter 10. Zebrafish neurobehavioral assays for drug addiction research. Henning Schneider

Chapter 11. Zebrafish behavioral models of ageing. Alistair J. Brock, Ari Sudwarts, Matthew O. Parker and Caroline H. Brennan

Chapter 12. Integrating morphological and behavioral phenotypes in developing zebrafish. Guozhu Zhang, Lisa Truong, Robert L. Tanguay and David M. Reif

Chapter 13. Neuroimaging phenotypes in zebrafish. Jeremy F.P. Ullmann and Andrew L. Janke

Chapter 14. Illustrated zebrafish neurobehavioral glossary. Allan V. Kalueff and the Zebrafish Neuroscience Research Consortium (ZNRC)

O autorze

Allan V. Kalueff is Professor of Translational Biomedicne at St. Petersburg State University. 

Blurb

Zebrafish (Danio rerio) is rapidly becoming a popular model organism in neuroscience research. The rights and wrongs of zebrafish, written by top experts in the field, summarizes the principles of behavioral neurophenotyping using this model species, and outlines the use of zebrafish to study the pathological mechanisms of neuropsychiatric disorders. The chapters discuss the use and interpretation of behavioral models to quantify emotional, cognitive, social and motor behaviors in zebrafish. This book will appeal to a wide spectrum of readership audience, from students to established investigators. The book will provide a valuable source of information for both the beginning zebrafish laboratories, and for those already actively working with zebrafish.