Preface to Fifth Edition viiUnits and Symbols viiiAbbreviations xGlossary xiiiAbout the companion website xviPart 1 Structure and function 11 Structure of the respiratory system: lungs, airways and dead space 22 The thoracic cage and respiratory muscles 43 Pressures and volumes during normal breathing 64 Gas laws 85 Diffusion 106 Lung mechanics: elastic forces 127 Lung mechanics: airway resistance 148 Carriage of oxygen 169 Carriage of carbon dioxide 1810 Acid-base balance 2011 Acid-base disorders 2212 Control of breathing I: chemical mechanisms 2413 Control of breathing II: neural mechanisms 2614 Pulmonary circulation and anatomical right- to- left shunts 2815 Ventilation-perfusion mismatching 3016 Exercise, high altitude and diving 3217 Development of the respiratory system and birth 3418 Complications of development and congenital disease 3619 Lung defence mechanisms 3820 Immunology of the lung 40Part 2 History, examination and investigation 4321 History and examination 4422 Pulmonary function tests 4623 Chest imaging and bronchoscopy 48Part 3 Diseases and treatment 5124 Public health and smoking 5225 Respiratory failure 5426 Asthma: pathophysiology 5627 Asthma: treatment 5828 Chronic obstructive pulmonary disease 6029 Pulmonary hypertension 6230 Venous thromboembolism and pulmonary embolism 6431 Pulmonary vasculitis 6632 Interstitial (diffuse parenchymal) lung disease 6833 Sarcoidosis 7034 Pleural diseases 7235 Occupational and environment- related lung disease 7436 Cystic fibrosis and bronchiectasis 7637 Pneumothorax 7838 Community- acquired pneumonia 8039 Hospital- acquired (nosocomial) pneumonia 8240 Pulmonary tuberculosis 8441 The immune- compromised patient 8642 Lung cancer 8843 Acute respiratory distress syndrome 9044 Mechanical ventilation 9245 Oxygenation and oxygen therapy 9446 Sleep disordered breathing 9647 Coronavirus disease 2019 98Index 100
Jeremy P.T. Ward, PhD, Emeritus Professor of Respiratory Cell Physiology, Asthma UK Centre in Allergic Mechanisms of Asthma, Faculty of Life Sciences and Medicine, King's College London, London, UK.Jane Ward, MBChB, PhD, Senior Lecturer (retired), Department of Physiology, King's College London, London, UK.Richard M. Leach, MD, FRCP, Medical Director, Cardiorespiratory and Critical Care Medicine Guy's and St Thomas' Hospital Trust, and Honorary Professor of Medicine Kings College London, London, UK.