The Renin Angiotensin System in Cardiovascular Disease

ISBN-13: 9783031149511 / Angielski / Twarda / 2023 / 452 str.

Naranjan S. Dhalla; Sukhwinder K. Bhullar; Anureet K. Shah

Opis

This book on “Renin-Angiotensin System in Cardiovascular Disease” includes 25 chapters, which are organized in three sections, namely (i) modulatory aspects, (ii) pathophysiological aspects, and (iii) pharmacotherapeutic aspects. It includes an updated as well as comprehensive knowledge about molecular and cellular aspects for the role of the renin-angiotensin system (RAS) in the pathophysiology and therapy of cardiovascular diseases such as hypertension, atherosclerosis, ischemic heart disease, and heart failure. This book emphasizes the molecular and cellular mechanisms, signaling transduction pathways involved in the development of different cardiovascular diseases due to the prolonged activation of RAS. Furthermore, biochemical mechanisms are outlined for the inhibition of this system by the blockade of angiotensin converting enzyme as well as angiotensin II type 1 receptors in patients suffering from cardiovascular abnormalities. Since cardiovascular disease is the number one cause of death worldwide, leading to approximately 17.9 million deaths each year, there is a keen interest in understanding the pathogenesis and improving its therapy. In this regard, we can attest that this book provides ample information about essential components of RAS and their role in the development of cardiovascular disease.

From the selection of recognized global experts in their area of investigation, this book can be seen to cover diverse cardiovascular aspects and molecular and cellular mechanisms of angiotensin II action for the development of different cardiovascular abnormalities. It is our contention that this book will be most suitable for promoting knowledge in the field of RAS biology and will be of great interest to health professionals involved in both experimental and clinical cardiology as well as academic investigators and cardiovascular scientists, graduate students, and fellows worldwide.

Spis treści

I. INTRODUCTION

1. Naranjan S. Dhalla

Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre

Winnipeg, Manitoba, Canada

Email: nsdhalla@sbrc.ca

Title: Past, present and future perspectives of renin angiotensin system

2. Anureet K. Shah 

Department of Kinesiology, Nutrition and Food Science, California State University 

Los Angeles, USA

Email: akaur23@calstatela.edu

Title: Biochemical pathways of renin angiotensin system

3. Ramesh K. Goyal

Delhi Pharmaceutical Sciences and Research University 

New Delhi, India

Email: goyalrk@gmail.com

Title: Structure-function relationships of angiotensin II receptors

4. Sukhwinder K. Bhullar

Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre

Winnipeg, Manitoba, Canada

Email: sbhullar@sbrc.ca

Title: Signal transduction mechanism of angiotensin II

5. Ernesto L. Schiffrin

Sir Mortimer B. Davis-Jewish General Hospital

Montreal, Canada

E-mail: ernesto.schiffrin@mcgill.ca

Title: Renin angiotensin system: Pathophysiology and clinical implications in cardiovascular disease COVID-19 infection 

II. HYPERTENSION

1. Carmine Savoia

Cardiology Unit, Second Faculty of Medicine, Sant 'Andrea Hospital, Sapienza University

Rome, Italy 

Email: savoiac@yahoo.it

Title: Angiotensin II and the pathogenesis of hypertension

2. Satoru Eguchi

Cardiovascular Research Center, Lewis Katz School of Medicine, Temple University

Philadelphia, USA

E-mail: seguchi@temple.edu

Title: Signaling transduction of angiotensin II in hypertension

3. Robert E. Widdop

Department of Pharmacology, Monash University, Clayton

Victoria, Australia 

Email: robert.widdop@monash.edu

Title: Role of angiotensin II type 1 receptors in vascular remodeling in hypertension

4. Rhian M. Touyz 

MRC Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal Montreal, Canada

Email: touyzr@ircm.qc.ca

Title: Molecular and cellular mechanisms of renin-angiotensin system in hypertension

5. Alessandro Celi

Department of Cardiothoracic and Vascular, University of Pisa

Pisa, Italy

Email: r.pedrinelli@med.unipi.it

Title: Tissue renin-angiotensin system and risks in hypertension

6. Shoji Kimura

Department of Pharmacology, Kagawa University Medical School

Kagawa, Japan

Email: kimura@kms.ac.jp

Title: Oxidative stress and angiotensin II-induced hypertension

7. Antony Vinh

Department of Pharmacology, Monash University, Clayton

Victoria, Australia 

Email: antony.vinh@monash.edu

Title: Angiotensin II: inflammatory system disorder and hypertension

8. Edward D. Sturrock 

Department of Integrative Biomedical Sciences

University of Cape Town

Cape Town, South Africa

E-mail: edward.sturrock@uct.ac.za

Title: Therapeutic approaches for angiotensin receptor blockers in hypertension

III. ATHEROSCLEROSIS

1. Domenico Cianflone

San Raffaele Scientific Institute, Vita-Salute San Raffaele University

Milan, Italy.

E-mail: cianflone.domenico@hsr.it

Title: Renin-angiotensin systems: A pivotal role in the development of atherosclerosis

2. Bernhard Schieffer

Department of Cardiology and Angiology, Hannover Medical School

Hannover, Germany

Email: Schieffer.Bernhard@MH-Hannover.de

Title: Angiotensin II induced intracellular signaling pathways in pathogenesis of atherosclerosis 

3. Maxime Pellegrin

Department of Heart and Vessel, Lausanne University Hospital 

Lausanne, Switzerland

Email: maxime.pellegrin@chuv.ch

Title: Cellular and molecular mechanisms of Ang II: Contribution to atherosclerotic plaque vulnerability

4. Ivonne H. Schulman

Nephrology-Hypertension Section, University of Miami Miller School of Medicine

Miami, USA

Email: ischulman@med.miami.edu

Title: Role of angiotensin II, nitric oxide and reactive oxygen species in atherosclerosis

5. Fabrizio Montecucco

Division of Cardiology, Foundation for Medical Researches, University Hospital of Geneva

Geneva, Switzerland

Email: fabrizio.montecucco@medecine.unige.ch

Title: The renin-angiotensin system and inflammatory processes in atherosclerotic lesion formation

6. Jawahar L. Mehta 

Department of Medicine, Cardiology Division, University of Arkansas for Medical Sciences

Little Rock, USA

Email: mehtajl@uams.edu

Title: Role of renin-angiotensin system in alterations in blood lipids and gene expression in atherogenesis 

7. Rafaela Fernandes da Silva

Department of Physiology and Biophysics, Federal University of Minas Gerais

Belo Horizonte, Brazil. 

Email: rfdasilva.ufmg@gmail.com

Title: Effects of angiotensin-converting enzyme and receptors in atherosclerosis 

IV. CARDIAC ARRHYTHMIAS

1. Andreas Goette

Division of Cardiology, University Hospital Magdeburg

Magdeburg, Germany

Email: andreas.goette@medizin.uni-magdeburg.de

Title: Effects of angiotensin II on cardiac arrhythmia and signal transduction 

2. Bibiana Torok

Institute of Experimental Medicine, 1085 Budapest, Hungary

Email: torok.bibiana@koki.hu

Title: Angiotensin II induced oxidative stress contribute to ventricular arrhythmias

3. Pieter Martens 

Doctoral School for Medicine and Life Sciences, Hasselt University

Diepenbeek, Belgium

Email: pieter.martens2@zol.be

Title: Modulation of renin angiotensin system: Beneficial effect on ventricular arrhythmias 

4. S. Richard 

Physiology and Experimental Medicine of the Heart and Montpellier 

France

Email: sylvain.richard@inserm.fr

Title: ACE inhibitor and ventricular arrhythmia in ischemic heart disease

5. J. R. Sowers 

Diabetes and Cardiovascular Research Center, University of Missouri School of Medicine

Columbia, USA

Email: Sowersj@health.missouri.edu.

Title: The renin-angiotensin system modulators and cardiac arrhythmias

6. David Cesario

University of California Irvine Medical Center

California, USA

Email: dcesario@mednet.ucla.edu

Title: Angiotensin receptor blockers in the treatment of arrhythmias

V. HEART FAILURE 

1. George W Booz 

The Cardiovascular Research Institute, The Texas University System Health Science Center

Temple, USA.

Email: gbooz@medicine.tamu.edu

Title: Angiotensin II induced cardiac hypertrophy and heart failure

2. Paramjit S. Tappia

Asper Clinical Research Institute, St. Boniface Hospital

Winnipeg, Canada

E-mail: ptappia@sbrc.ca

Title: Renin-angiotensin system: Role in cardiac remodeling and subcellular defects in heart failure 

3. Walmor C De Mello

Department of Pharmacology, Medical Sciences Campus, University Puerto Rico

San Juan, USA 

Email: wmello@rcm.upr.edu

Title: Renin-angiotensin system: Molecular and cellular mechanisms in heart failure

4. Angelica Wackenfors

Department of Internal Medicine, Lund University Hospital

Lund, Sweden

Email: angelica.wackenfors@med.lu.se

Title: Role of angiotensin II receptor mRNA expression in heart failure 

5. Po‐Len Liu 

Regenerative Medicine and Cell Therapy Research Center, Kaohsiung Medical University

Kaohsiung, Taiwan.

Email: kisa@kmu.edu.tw

Title: Renin angiotensin system: Mitochondrial dysfunction in the progression of heart failure 

6. Fu-Tien Chiang

Department of Internal Medicine, National Taiwan University College of Medicine and Hospital,

Taipei, Taiwan 

Email: futienc@ntuh.gov.tw

Title: Angiotensin II type 1 receptor: Genetic polymorphisms and heart failure

7. G.Y. Oudit

Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta 

Edmonton, Canada

Email: gavin.oudit@ualberta.ca

Title: Angiotensin converting enzyme 2 and angiotensin metabolism in heart failure 

8. L. Zhang 

Department of Basic Sciences, Division of Pharmacology, Loma Linda University School of Medicine, Loma Linda, USA

Email: lzhang@llu.edu

Title: Cellular and molecular mechanisms of renin-angiotensin system blockade in heart failure: An update

9. Kazuhiro Yamamoto

Department of Internal Medicine and Therapeutics, Osaka University of Medicine 

Suita, Japan

Email: kazuhiro@medone.med.osaka-u.ac.jp

Title: Angiotensin II receptor antagonists: Modulation of the extracellular matrix regulatory system in heart failure