The Opiate Receptors

ISBN-13: 9781617797217 / Angielski / Miękka / 2013 / 516 str.

Gavril W. Pasternak

Opis

This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.

Recenzje

From the reviews of the second edition:

"It is intended as a review and reference resource on topics of interest to scientists working in the opioid receptor field. ... would be most appropriate for midlevel graduate students and higher level researchers ... . The book offers a detailed overview and review of 14 different aspects of opioid receptor science ... . an excellent source for a graduate level course on opioid pharmacology, or would serve well as a current reference point on timely issues in this field of research." (Kenneth E. McCarson, Doody's Review Service, June, 2011)

"The major goal of this second edition of The Opiate Receptors is to provide insight into the molecular and classical pharmacology of opiates and opioid peptides and to translate this into pharmacological actions. Gavril Pasternak ... does a masterful job of bringing all of this together. ... This book will be a valuable resource for scientists working in the opiate field and for clinicians who are interested in the pharmacological actions of these agents." (Dwight Moulin, Canadian Journal of Neurological Sciences, March, 2012)

Spis treści

Chapter 1: You’ve Come a Long Way Baby! Solomon H. Snyder Chapter 2: The evolution of concepts of opioid receptors William R. Martin Chapter 3: Pharmacology of opioid drugs Brian M. Cox Chapter 4: Opioid receptors: the early years Gavril W. Pasternak Chapter 5: Endogenous opioids Iryna Berezniuk, Lloyd D. Fricker Chapter 6: Molecular biology of mu opioid receptors Ying-Xian Pan, Gavril W. Pasternak Chapter 7: Delta Opioid Receptors Wendy Walwyn, Fatima Macho Sánchez-Simon, Raquel Rodriguez, Christopher J. Evans Chapter 8: Kappa opioid receptor gene and the regulatory mechanisms of its protein expression Li-Na Wei, Horace H. Loh Chapter 9: Opioid receptor signal transduction mechanisms Ping-Yee Law Chapter 10: Mu opioid receptor mediated analgesia and reward Howard L. Fields Chapter 11: Kappa opioid receptor function Julia C. Lemos, Charles Chavkin Chapter 12: Delta opioid receptor function Edita Navratilova, Victor J. Hruby, Frank Porreca Chapter 13: Genetics of opioid receptor functions in mice Michael A. Ansonoff, Ting Wen, John E. Pintar Chapter 14: Opioid receptor trafficking Mark VonZastrow Chapter 15: Opioid receptor dimerization Raphael Rozenfeld, Ivone Gomes, Lakshmi A. Devi Chapter 16: Molecular modulation of in vivo tolerance Charles E. Inturrisi, Ann M. Gregus Chapter 17: Genetics of opioid actions Jörn Löetsch, Jeffrey S. Mogil

O autorze

In 1988, Gavril W. Pasternak published the first edition of The Opiate Receptors. Dr. Pasternak is affiliated with the Molecular Pharmacology & Chemistry department at the Sloan-Kettering Institute (Memorial Sloan-Kettering Cancer Center).

Blurb

In 1988, Gavril W. Pasternak published the first edition of this seminal text. It was a lucid account of the latest knowledge on opiate receptors and related receptor subtypes, a then controversial field, providing an integrated approach correlating the biochemical, physiological, and pharmacological aspects of opiate reaction. Fully revised and expanded, The Opiate Receptors, 2nd edition presents all the advances made in the field in the past twenty years. It covers a wide variety of topics including, but not limited to, the following: pharmacology of opioid drugs; endogenous opioids; molecular biology of mu receptors; molecular biology of delta receptors; kappa opioid receptor gene and the regulatory mechanisms of its protein expression; opioid receptor signal transduction mechanisms; mu opioid receptor mediated analgesia and reward; kappa opioid receptor function; delta opioid receptor function; genetics of opioid receptor functions in mice; opioid receptor trafficking; opioid receptor dimerization; molecular modulation of in vivo tolerance; and genetics of opioid actions. Written by leading international researchers in the field, this new edition is as groundbreaking and vital as its predecessor.