The Neuroscience of Dementia

ISBN-13: 9780128160435 / Angielski / Other / 2020

Colin R. Martin; Victor R. Preedy

Recenzje

"This book is a must-have for anyone dealing with dementia in their clinical practice or research." --Doody

Spis treści

DIAGNOSIS AND MANAGEMENT IN DEMENTIA

I. Dementia: Introductory Chapters and Setting the Scene1. Mixed dementia: an overview; 2. Vascular dementia: an overview; 3. Small vessel disease and dementia; 4. Linking Amyotrophic lateral sclerosis (ALS) and Frontotemporal dementia; 5. Mortality in dementia: linking in delirium; 6. Midlife diabetes and the risk of dementia- understanding the link; 7. Gait and Alzheimer's disease /Gait and dementia; 8. Hypertension and dementia; 9. Genetics of dementia: focus on Alzheimer's disease; 10. Clinical and pathological phenotypes in autosomal dominant frontotemporal dementia; 11. Risk factors in dementia: genetic and nongenetic; 12. Lipidomics and biomarker in Alzheimer's disease; 13. The 5xFAD mouse model of Alzheimer's disease

II. Biomarkers, Psychometric Instruments and Diagnosis14. Use of cerebrospinal fluid in diagnosis of dementia; 15. Salivary biomarkers in Alzheimer's disease; 16. Diacylglycerols as biomarkers in dementia; 17. Butyrylcholinesterase (BChE) as a biomarker in Alzheimer's disease; 18. Blood brain-derived neurotrophic factor as a biomarker of Alzheimers disease; 19. Methods of amyloid PET Imaging and its applications to Alzheimer's disease spectrum; 20. Applications of diffusion-weighted imaging (DWI) Tractography and Alzheimer's disease; 21. Transcranial Magnetic stimulation and diagnostic applications to dementias; 22. Retinal imaging and dementia as a diagnostic tool; 23. The prediction of Alzheimer's disease; 24. Addenbrooke's Cognitive Examination; 25. The Montreal Cognitive Assessment (MoCA) and applications to dementia; 26. ALBA Screening Instrument (ASI) and applications to dementia; 27. The Quick Mild Cognitive Impairment (Qmci) screen and applications to dementia; 28. Assessment of activities of daily living (ADL) applied to dementia

III. Pharmacological Treatments for Dementia29. Cholinesterase inhibitors in dementias: an overview; 30. Choline-containing phospholipids and treatment of adult-onset dementia disorders; 31. Donepezil usage: a focused review; 32. Memantine: a focused review; 33. The benefits of calcium channel blockers for the therapy of dementia; 34. Pitfalls for pharmacotherapeutic trials in dementia; 35. All-trans retinoic acid in Alzheimer's disease; 36. Dementias and usage of NMDA receptor antagonists; 37. Dementia and bladder dysfunction: a focus on treatments with anticholinergics; 38. Linking astrocytes' exosomes to Alzheimer's pathogenesis and therapy; 39. Changing the fate: therapeutic mechanisms focus on the switch of beta-amyloid precursor protein (APP) processing; 40. Acetylcholinesterase inhibitory agents in plants and application to dementia: Alzheimers Disease; 41. Removal of blood amyloid as a safety strategy

IV. Non-Pharmacological Treatments and Procedures42. Caring for people with Dementia in the Acute Hospital; 43. Environmental enrichment in dementia; 44. Music therapy in dementia; 45. Aromatherapy in dementia; 46. Dancing in dementia; 47. Hypoxic-hyperoxic training and dementia; 48. Linking amyloid and depression in dementia: effects of treatments by non-drug means; 49. Regional dementia care networks; 50. Cognitive behavioural therapy (CBT) use in Alzheimer's disease; 51. Maximizing cognition in Mild Cognitive Impairment and early-stage dementia; 52. Exercise, cognitive creativity, and dementia; 53. Linking care staff, person-focused communications and dementias

GENETICS, NEUROLOGY, BEHAVIOR, AND DIET IN DEMENTIA

I. Genetics, Molecular and Cellular Biology1. The genetics of Alzheimer's disease: a focus on the neuron navigator 2 gene; 2. Interlinking polymorphisms, estrogens and Alzheimer's disease; 3. Linking EEGs, Alzheimer's disease and the Phosphatidylinositol binding clathrin assembly protein (PICALM) gene; 4. CD36 gene polymorphism and Alzheimer's disease; 5. Genetic contributions to sporadic frontotemporal dementia; 6. Dementia and CYP2D6 polymorphisms; 7. A1 purinergic receptor gene expression in dementia; 8. Molecular aspects of metallothionein-1 in dementias; 9. MicroRNAs in Alzheimer's disease; 10. Oxidative stress and neurons in dementia; 11. Toward an integrative understanding of the neuroinflammatory molecular milieu in Alzheimer's disease neurodegeneration; 12. Wnt Signalling and dementia; 13. Linking PKC, PKClambda/I and Alzheimer's disease; 14. Linking histone deacetylases, phosphodiesterase 5 and novel treatments Alzheimer's disease; 15. Linking Nrf2 and Alzheimer's disease; 16. Role of alpha- and beta-secretase in Alzheimer's disease; 17. Methylation analysis of DNA in Alzheimer's disease; 18. The signalosome malfunctions in age-associated neuropathologies; 19. ILEI/FAM3C in Alzheimer's disease; 20. Amylin and Alzheimer's disease; 21. Mammalian target of rapamycin (mTOR) complexes: Regulation and Alzheimer's disease; 22. Mammalian target of rapamycin (mTOR) complexes: Protein synthesis and autophagy, Parkinson's Disease, Amyotrophic Lateral Sclerosis and frontotemporal dementia; 23. Linking CD200 in brains and dementia: molecular aspects of neuroinflammation

II. Neurological, Physiological and Imaging 24. Hippocampal atrophy and dementia; 25. Inflammation and insulin resistance in AD: partners in crime; 26. Neuronal susceptibility to hypoxia in Alzheimer disease; 27. Neuropeptides and Neurolipids: what they are and how they relate to Alzheimer's disease; 28. Brain receptors in Alzheimer's disease; 29. Abeta42-alpha7-like nicotinic acetylcholine receptors and Alzheimer's disease; 30. Synaptosomal bioenergetics in Alzheimer's disease; 31. Limitations of amyloid-PET imaging; 32. Linking Gradient Echo Plural Contrast Imaging (GEPCI) Metrics of Tissue Microstructure with Alzheimer's disease; 33. Hypertensive disorders in pregnancy and later dementia; 34. Sleep architecture and the development of clinical dementia

III. Behaviour and Psychopathology35. An overview of behavioural and psychiatric symptoms of dementia; 36. Delirium superimposed on dementia: from diagnosis to treatment; 37. Self-Consciousness Deficits in dementia; 38. Attention impairments, novel images and Alzheimer's disease; 39. Frontal Lobe Syndrome and Dementias; 40. The stigma of dementia; 41. Delusions in dementias; 42. Linking motor speech function and dementia; 43. Spatial Navigation and Alzheimer's disease; 44. Violence and dementia; 45. Caregiver depression in dementia

IV. Diet, Nutrition and Environment 46. Nutritional status in dementia; 47. Selenium and Alzheimer's disease; 48. Linking adiponectin and obesity in dementia; 49. The gut microbiome in Alzheimer's disease; 50. (-)-epigallocatechin-3-gallate (EGCG) and Alzheimer disease; 51. Cadmium and Alzheimer's disease

V. Models And Modelling In Dementia52. Alzheimer's model 5xFAD mice as a model and applications to dementia; 53. Use of 192 IgG-saporin as a model of dementia and its application; 54. Abeta1-42 oligomer animal model of dementia