The Neuroscience of Aging

ISBN-13: 9780128183694 / Angielski / Mixed media product / 2021 / 1352 str.

Spis treści

Assessments, Treatments and Modeling in Aging and Neurological Disease: The Neuroscience of Aging

I. Introductory chapters: Setting the scene for the neuroscience of aging 1. The concept of productive aging; 2. Quality of life in the over 80s; 3. Successful aging and diet; 4. The impact of positive social relations on the quality of life of older people. An alternative to medicalization from an integral perspective; 5. The brain in life span: use of phase fMagnetic Resonance Imaging (MRI); 6. Neuronal structure in aging: Cytoskeleton in health and disease; 7. Sporadic Alzheimer's Triad: Age, Sex, and ApoE; 8. How polymorphisms impact: BDNF polymorphism, inhibitory performance and the elderly; 9. Menopause as an aging process and alcohol misuse; 10. Brain banking and aging

II. Impairments and Diseases11. Dementia or no dementia in the very elderly. Why?; 12. Neuropsychology, Social Cognition and Loss of Insight in Frontotemporal Dementia; 13. Neuroinflammation in the elderly; 14. Cortical microinfarcts and the aging brain; 15. Vascular brain injury and neurodegeneration in elderly racial and ethnic minority populations; 16. Hearing loss amongst the elderly; 17. Aging Auditory Cortex: The Impact of Reduced Inhibition on Function; 18. Aging and vestibular disorders; 19. Brain aging in HIV and antiretrovirals; 20. Antioxidants, Methylmercury, and Aging; 21. Aging and the effects of ethanol on the brain: Comparing the effects of different aging

III. Biomarkers And Diagnosis 22. Aging brain: Radiological biomarkers; 23. Plasma ADAM10 as a biomarker of mental impairment in the elderly; 24. Circulating microRNAs as biomarkers of healthy elderly; 25. DHEA as a biomarker of aging in humans and nonhuman primates: Synthesis, neuroprotection and cognitive function; 26. Evaluation of subjective memory abilities in elderly people; 27. The Functional Activities Questionnaire: Applications to aging; 28. Autobiographical memory as a diagnostic tool in aging; 29. Assessment tools for subjective memory abilities in elderly people; 30. Knowledge of Memory Aging

IV. Management and Treatments 31. Pharmacological use of transient receptor potential (TRP) ion channel antagonists in neurological disease: effects on swallowing and implications for nutrition; 32. Aripiprazole: features and use in the aged; 33. Cognition-Enhancing Drugs and Applications to Aging; 34. Creatine supplementation and impact on the aging brain; 35. Photobiomodulation as a brain-boosting strategy in aging; 36. Innovation in deep brain stimulation in aging: a focus on Parkinson Disease; 37. Exergames: what they are and how they can be used to improve cognition in aging; 38. Linking cognitive decline and ballroom dance as a therapeutic intervention in the elderly; 39. Active experiencing training in the elderly; 40. Psychiatric self-management, smartphone apps and older adults; 41. Psychosocial Interventions for Suicide Prevention in the Elderly: Advances and Future Directions

V. Models And Modelling42. D-galactose-induced aging and brain mitochondria; 43. Drosophila as a model organism in ageing research; 44. The Zebrafish (Danio rerio) and its uses for understanding the neuroscience of aging: applications and observation; 45. Murine models of primary Tauopathy as a model of aging; 46. Modelling nutrition and brain aging in rodents; 47. Modelling primates and neurological aging: a focus on Alzheimer's disease; 48. Linking aging and animal models to neurodegeneration: the Striatum, Substantia Nigra and Parkinson's Disease; 49. Behavioral evaluation of aging

VI. Resources50. Research and recommended resources in the neuroscience of agingFactors Affecting Neurological Aging: Genetics, Neurology, Behavior, And Diet

I. Genetics, Molecular and Cellular Biology1. Genetics of frontotemporal dementia; 2. Aging, brain-derived neurotrophic factor (BDNF) and its polymorphism; 3. Aging, demented patients, and polymorphisms in cytokine genes; 4. RNA fragments and brain aging; 5. Centrosome functions and remodeling during neuronal development and centrosome abnormalities in neuronal disorders, disease, and in aging; 6. Brain aging and microarray analysis; 7. Human nuclear tau and aging; 8. Lipoxidation: features, neurological tissues and aging; 9. Aging and brain amino acids; 10. How 3',5'-cyclic nucleotide phosphodiesterases change in the brain with normal aging and dementia; 11. The prohibitin complex in aging and neurodegeneration; 12. Synaptic ATPase and energy metabolism in the nervous system: roles and changes in the aging process

II. Neurological and Imaging Features13. Microstructural Imaging of the Human Brain with Normal and "Abnormal" Aging using Diffusion Magnetic Resonance Imaging; 14. Imaging the brain and its vascular in aging: applications of optical coherence tomography angiography; 15. Potential involvement of perineuronal nets in brain aging: an anatomical point of view; 16. Grey-matter networks in aging; 17. Brain synapse-related proteins what they do and how they change in aging; 18. Macro- and chaperone-mediated autophagy in aging; 19. Neuronal L-type calcium channels in aging; 20. D-serine-regulated glutamatergic transmission and microglia: impact of aging; 21. Voltage-gated potassium channels and the aging brain; 22. Dendritic spine remodeling and aging; 23. High-density lipoprotein-cholesterol and neuroaging: memory, gyrification of the insular and frontal opercular cortex; 24. Astrocyte and microglial aging: morphology and modelling; 25. Neural scaffolding: features, profiles and the aging cerebellum; 26. BACE1 RNAi, memory and aging; 27. Aging, myelination and the optic nerve; 28. Linking proteostasis, brain aging, and ischemia; 29. Luteinizing hormone and the aging nervous system; 30. Insights into aging using transcranial magnetic stimulation; 31. Alpha rhythms: What they are and how they alter with aging; 32. Nicotine and its derivatives in healthy brain aging

III. Physiological Aspects 33. Environmental enrichment and physiological aging; 34. Treadmill exercise and neuroinflammation: links with aging; 35. Impact of aerobic exercise on brain structure in models of aging: hippocampus and beyond; 36. The physiology of fitness and the brain in aging; 37. Aging, Babble Noise and the processing of speech perception; 38. The blood-brain barrier in aging

IV. Behavior And Psychopathological Aspects 39. Linking aging, anticholinergic drug use, and cognitive impairment; 40. Cognitive Frailty: Definition, components and impact on disability, and mortality; 41. The physiology of the "Brain-muscle loop" in aging; 42. Disentangling the effects of aging and ovarian hormone loss on sleep: Implications for health and disease; 43. Role of DNA methylation in aging-related cognitive functioning'; 44. Depression in the elderly and psychobiotics

V. Diet And Nutrition45. Aging, dietary patterns and cognition; 46. Geriatric nutritional risk index: Application, and limitations; 47. Diet, inflammatory biomarkers, and brain aging; 48. DASH diet and brain aging; 49. The ketogenic diet and healthy brain aging; 50. Autophagy and aging: diet, exercise, and the link with the target of rapamycin complex 1 (TORC); 51. Dietary Flavonoids and Brain Health in Ageing: food for Thought; 52. Antioxidant effects of curcumin and neuroaging; 53. Lipoic acid and vitamin D3 and their use in preventing brain aging; 54. Aging and working memory: Impact of the leucine metabolite beta hydroxy-beta-methyl butyrate; 55. Hydration, the brain and aging