The Mouse in Biomedical Research: Immunology Volume 4

ISBN-13: 9780123694584 / Angielski / Twarda / 2006 / 374 str.

James G. Fox; Stephen W. Barthold; Muriel T. Davisson

Opis

Immunology, the third volume in the four volume set, The Mouse in Biomedical Research, is a completely new addition to this series, dedicated to mouse immunology. It is based on the vast body of knowledge which has made the mouse the model of choice when studying immunity in man. Arguably more is known about the immune system in mice than any other species except man. In large part this is due to the power of genetic engineering to delineate molecular mechanisms. In this volume we present an Overview to mouse immunology, including both the innate and adaptive immune systems, followed by 15 chapters, each dealing with a specific area of immunology in the mouse. These chapters illustrate the power of genetic engineering in dissecting each component of the immune response from the development of lymphoid tissues to signal transduction pathways in activated cells.

Spis treści

1. The Molecular Basis of Lymphoid Architecture in the Mouse
2. The Biology of Toll-like Receptors in Mice
3. Genomic Organization of the Mouse Major Histocompatibility Complex
4. Some Biological Features of Dendritic Cells in the Mouse
5. Mouse Models Revealed the Mechanisms for Somatic Hypermutation and Class Switch
Recombination of Immunoglobulin Genes
6. Mouse Natural Killer Cells: Function and Activation
7. Cytokine-activated JAK-STAT Signaling in the Mouse Immune System
8. Signal Transduction Events Regulating Integrin Function and T Cell Migration in the Mouse
9. Mouse Models of Negative Selection
10. Peripheral Tolerance of T Cells in the Mouse
11. The Genetics of Mouse Models of Systemic Lupus
12. Inhibitory Receptors and Autoimmunity in the Mouse
13. Mouse Models of Immunodeficiency
14. Mouse Models to Study the Pathogenesis of Allergic Asthma
15. The Mouse Trap: How Well Do Mice Model Human Immunology?

O autorze

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.