The Mouse in Biomedical Research: History, Wild Mice, and Genetics Volume 1

ISBN-13: 9780123694553 / Angielski / Twarda / 2006 / 326 str.

James G. Fox; Stephen W. Barthold; Muriel T. Davisson

Opis

History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.

Spis treści

1. Building a Better Mouse: One Hundred Years of Genetics and Biology
2. Systematics of the genus Mus
3. The Secret World of Wild Mice
4. Breeding Systems: Considerations, Genetic Fundamentals, Genetic Background, and Strain Types
5. Mouse Strain and Genetic Nomenclature: an Abbreviated Guide
6. The Mouse Genome
7. Gene Mapping
8. Genetic Monitoring
9. Cytogenetics
10. Mouse Embryology: Research Techniques and a Comparison of Embryonic Development between Mouse and Man
11. Gamete and Embryo Manipulation
12. Chemical Mutagenesis in Mice
13. Gene-Specific Mutagenesis
14. Gene Transfer Studies Using Mouse Models
15. Mouse and Human Pluripotent Stem Cells
16. Drugs and the Mouse: Pharmacology, Pharmacogenetics, and Pharmacogenomics