The Molecular and Clinical Pathology of Neurodegenerative Disease

ISBN-13: 9780128110690 / Angielski / Miękka / 2018 / 274 str.

Patrick a. Lewis; Jennifer E. Spillane

Opis

The Molecular Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. There are a large number of existing books covering this subject aimed at a clinical audience (both at undergraduate and higher level), however the increasing interest in neurodegeneration for more basic science courses - neuroscientists, biologists, pharmacists and so forth - highlight the need for a book tailored for this audience.

• Provides an up-to-date summary to our current understanding of neurodegeneration at a molecular, cellular and tissue level for the most common human disorders
• Includes clinical vignettes, so that basic science students can relate underlying molecular processes to clinical symptoms
• Provides background on the history of neurodegeneration
• Highlights the state-of-the-art treatment options for each disorder
• Includes examples of cutting edge experimental systems for investigating these disorders (e.g. optogenetics, human pluripotent stem cell derived neuronal models)

Spis treści

1. An Introduction to Neurodegeneration2. Alzheimer's Disease and Dementia3. Parkinson's Disease4. The Prion Diseases5. The Motor Neuron Diseases and Amyotrophic Lateral Sclerosis6. Huntington's Chorea7. Multiple Sclerosis

O autorze

Dr. Lewis has been involved in research into neurodegeneration for over 15 years, investigating dementia, the prion diseases and, for the last 10 years, Parkinson's disease. He has published over 50 peer-reviewed publications in the field of neurodegeneration, and organized a number of international conferences on Parkinson's disease, with a particular focus on Leucine Rich Repeat Kinase 2 (LRRK2). With over a decade of teaching experience, he instructs on a wide range of neuroscience-related topics to both undergraduate and postgraduate students at the University of Reading and University College London. Dr. Jennifer Spillane is a neurology specialist registrar at the National Hospital for Neurology and Neurosurgery. She completed her PhD at the Institute of Neurology and has published peer-reviewed articles over a wide range of neurological topics. She has experience teaching both undergraduate and post graduate medical students.