The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms

ISBN-13: 9780128113042 / Angielski / Twarda / 2018 / 560 str.

Michael S. Wolfe

Opis

The Molecular and Cellular Basis of Neurodegenerative Diseases presents the pathology, genetics, biochemistry, and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, chapters explore their pathogenic commonalities and differences, and also include discussion of animal models and prospects for therapeutics. The book uniquely presents diseases first, common mechanisms later - individual chapters discuss each major neurodegenerative disease, followed by chapters that integrate this information to offer multiple molecular and cellular mechanisms that these diseases may have in common, including protein misfolding, compromising protein degradation, disrupted axonal transport, dysfunctional mitochondria, toxic contributions by non-neuronal cells, RNA-mediated toxicity, and neuroinflammation. This book provides readers with a timely update on this rapidly advancing area of investigation and is invaluable for researchers in the field.

• Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical, and cellular features
• Chapters focus on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration
• Details features, advantages, and limitations of animal models as well as prospects for therapeutics development
• Authored by internationally recognized leaders in the field
• Includes illustrations that help clarify and consolidate complex concepts

Spis treści

1. General Overview 2. Prion Diseases 3. Alzheimer's disease: towards a quantitative biological approach in describing its natural history and underlying mechanisms 4. Neurodegeneration and the ordered assembly of Tau 5. ALS and Other TDP43 Proteinopathies 6. Parkinson's Disease and Other Synucleinopathies 7. Huntington's Disease and Other Polyglutamine Disorders 8. Prion-like propagation in Neurodegenerative Diseases 9. Neurodegenerative Diseases as Protein Folding Disorders 10. Heat shock proteins and protein quality control in Alzheimer's disease 11. Neurodegenerative Diseases and Autophagy 12. Neurodegenerative Diseases and Axonal Transport 13. Mitochondrial Function and Neurodegenerative Diseases 14. Neurodegenerative Diseases and Non-cell autonomous toxicity 15. Neurodegenerative Diseases and RNA-mediated toxicity 16. Neuroinflammation in Age-Related Neurodegenerative Diseases 17. Neurodegenerative Diseases and the Aging Brain

O autorze

Michael S. Wolfe is the Mathias P. Mertes Professor of Medicinal Chemistry at the University of Kansas. He received his B.S. in chemistry in 1984 from the Philadelphia College of Pharmacy and Science and Ph.D. in medicinal chemistry in 1990 from the University of Kansas. After postdoctoral stints at the University of Kansas (medicinal chemistry) and the NIH (cell biology), he joined the faculty of the University of Tennessee in Memphis in 1994. In 1999, he joined the faculty at Brigham and Women's Hospital and Harvard Medical School in Boston, becoming Professor of Neurology in 2008. Prof. Wolfe's work has focused on understanding the molecular basis of Alzheimer's disease and related disorders, and identifying effective approaches for pharmacological intervention. Awards for his work include the Sato Memorial International Award in bioorganic and medicinal chemistry from the Pharmaceutical Society of Japan (2003), the MetLife Award for Biomedical Research (2008), a Zenith Fellows Award from the Alzheimer's Association (2008), and the Potamkin Prize from the American Academy of Neurology (2009).