The Microtubule Cytoskeleton: Organisation, Function and Role in Disease

ISBN-13: 9783709119013 / Angielski / Miękka / 2016 / 189 str.

Jens Luders

Opis

This book provides an overview on the organization and function of the microtubule cytoskeleton, which is essential to many cellular processes and profoundly linked to a range of human diseases. Covering basic concepts as well as molecular details, the book discusses how microtubules are nucleated and organized into ordered arrays, at different cell cycle stages and in distinct cell types. In addition, the book highlights how defects in the microtubule cytoskeleton are linked to diseases such as neurodevelopmental disorders. The book is intended for students, graduates and more senior researchers in cell and developmental biology as well as for medical doctors.

Spis treści

Part 1. Organization of the microtubule cytoskeleton Microtubule nucleators.- Microtubule regulators.- Microtubule organizing centers. Part 2. Assembly, maintenance and function of microtubule-based organellesCentrioles/basal bodies.- Centrosomes.- Cilia. Part 3. The microtubule cytoskeleton and disease Microtubule-based.- Centrosome-based.- Ciliopathies.​

O autorze

Jens Lüders, PhD, is leading the Microtubule organization group at the Institute for Research in Biomedicine (IRB), in Barcelona, Spain.