The Metabolic Syndrome: Epidemiology, Clinical Treatment, and Underlying Mechanisms

ISBN-13: 9781588297389 / Angielski / Twarda / 2008 / 420 str.

Barbara C. Hansen; George A. Bray

Opis

In the United States, 40 to 45% of those over 60 years of age have the metabolic syndrome (1,2,3), and this percentage, based on estimates of the increasing prevalence ofexcess body weight and the more comprehensive diagnostic criteria for the syndrome, is likely to exceed 60% in newer survey analyses. Children and adolescents, too, are being affected by the metabolic syndrome, in parallel with the increasing prevalence of overweight in young people, now estimated to include 16% of those age 6 to 19 years. Clinicians see with increasing frequency that routine office visits demonstrate the meta- bolic syndrome, a constellation of discrete but closely related metabolic disturbances indicative of increased risk for (or presence of) cardiovascular disease and/or diabetes. All estimates suggest the increasing impactof the metabolic syndrome on mortality and morbidity (4). Our aim in developing this new synthesis and analysis of the metabolic syndrome has been to bring together the viewpoints of the epidemiologists, the physiologists, the molecular biologists/biochemists, and the clinicians toward understanding the current state ofknowledge ofboth the causes and the consequences of the metabolic syndrome. These writers aim to stimulate new thinking concerning underlying mechanisms and to encourage heightened efforts to develop new therapeutics, potentially targeting uniquely intersecting pathways or points of intervention. This book is an extended call to action to slow or halt the rising tide of the metabolic syndrome (5).

Recenzje

From the reviews:

"This book presents a balanced view of the controversies surrounding the metabolic syndrome and supplies the reader with a detailed account of the key issues that divide the various camps. ... is an admirable collection of scientifically focused and up-to-date views of the current thinking on the metabolic syndrome. It can be recommended for scientists working in this field as well as for clinicians who wish to gain a deeper understanding of this complex syndrome." (Arne Astrup, The New England Journal of Medicine, July, 2008)

"This book covers three major perspective of the metabolic syndrome ... . this book is written for an endocrinology audience and anyone who has a strong interest in the link between the basic science of insulin resistance and the clinical manifestations of the metabolic syndrome. Practitioners will find useful information about the underlying mechanisms of the disease as well as an overview of treatment approaches. ... This is a high quality review of insulin resistance targeted at endocrinologists and basic scientists." (Matthew J. Sorrentino, Doody's Review Service, November, 2008)

Spis treści

Part I: Epidemiology and Clinical Treatment: Issues in defining and treating the metabolic syndrome Chapter 1 Metabolic Syndrome: to be or not to be? Gerald M. Reaven Chapter 2 The Role of Obesity in Insulin Resistance: Epidemiological and metabolic aspects James B. Meigs Chapter 3 Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery George A. Bray Chapter 4 Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease: an epidemiological perspective Earl Ford and Simin Liu Chapter 5 The Sympatho-Adrenal System in Metabolic Syndrome Lewis Landsberg Part II: Endothelial Function, Inflammation, and Dyslipidemia Chapter 6 Insulin Action and Endothelial Function Kieren J. Mather, Alain Baron, and Michael J. Quon Chapter 7 Macro and Micro Vascular Disease in an Insulin Resistant - Pre-diabetic Animal Model (the JCR:LA-cp Rat) James C. Russell and Spencer D. Proctor: Chapter 8 High Sensitivity C-reactive protein (Hs-CRP) in Metabolic Syndrome Yiqing Song, Simin Liu, and JoAnn Manson Chapter 9 Insulin Signaling in Adipocytes and the Role of Inflammation Christian X. Andersson, Ann Hammarstedt, Per-Anders Jansson and Ulf Smith Chapter 10 Insulin Resistance and Dyslipidemia Tina J. Cahil, Gissette Reyes, and Henry N. Ginsberg Part III: Insulin — Secretion and Action: Underlying mechanisms of the metabolic syndrome Chapter 11 Pancreatic Islet Pathophysiology and Pathology in Obesity Anne Clark, Jenni Moffitt, Leanne van de Laar, Katherine Pinnick, Farhina Sayyed Chapter 12 Glucagon Peptides and Insulin Sensitivity Jens Juul Holst and Filip Krag Knop Chapter 13 The Relationship between the Insulin Receptor Substrates and Metabolic Disease Morris F. White Chapter 14 Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase Jack F. Youngren Chapter 15 Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance: an update E.W. Kraegen, G.J. Cooney, J.M. Ye, and S.M. Furler: Chapter 16 Alternations in Atypical Protein Kinase-C (APK-C) Activation in Insulin Resistance Syndrome Robert V. Faresse Chapter 17 The Liver’s Role in Insulin Action and Resistance

Blurb

With an extraordinary need for early intervention and prevention to slow or halt its progression, Metabolic Syndrome is one of the most challenging health problems. Only through an understanding of the science underlying this syndrome can successful interventions be developed and implemented. In The Metabolic Syndrome: Epidemiology, Clinical Treatment, and Underlying Mechanisms, the writers stimulate new thinking concerning underlying mechanisms and encourage heightened efforts to develop new therapeutics, potentially targeting uniquely intersecting pathways. Developing this new synthesis and analysis of the Metabolic Syndrome will bring together the viewpoints of epidemiologists, physiologists, molecular biologists/biochemists, and clinicians toward understanding the current state of knowledge of both the causes and consequences of the Metabolic Syndrome.