The Menopause and Postmenopause: The Proceedings of an International Symposium Held in Rome, June 1979

ISBN-13: 9789401172325 / Angielski / Miękka / 2012 / 322 str.

Rodolfo Paoletti; N. Pasetto; J. L. Ambrus

Opis

The treatment of menopausal and postmenopausal symptoms is a focus of considerable debate, on account of both the medical and social factors involved. And perhaps the cause of the greatest current interest and concern is not so much the effectiveness of present-day treatment but its safety. Opinions on the subject vary; and to resolve the arguments we must turn to the results of scientific experiment, both the clinical and biological. It is only by comparing experimental results that it is possible to move forward, albeit slowly, towards a generally agreed consensus based upon objective scientific data. It is for this reason that we are particularly grateful to Ayerst Laboratories whose support and help have enabled us to turn our original proposal for an International Symposium into a reality. We are also grateful to the publishers for the efficiency with which they have organized the publication of the Proceedings. It is our hope and that of all the distinguished participants that all readers of this volume will be able to find something in it which will stimulate further thought and discussion - even though they may not necessarily agree with all the conclusions expressed - for the success of a Symposium turns not only on the subject under examination but also on the quality of debate and discussion it encourages.

Spis treści

Section I Pharmacological update.- 1 Chemistry and biochemistry of natural estrogens.- 2 Estrogens and prostaglandins.- 3 Plasma concentration of estrogens after application of various estrogen preparations.- 4 Progestogen modification of estrogen-induced endometrial proliferation in climacteric women.- 5 New concepts of estrogenic activity : the role of metabolites in the expression of hormone action.- Section II Clinical update.- 6 Hormonal influences on ?-adrenoreceptors: preliminary results.- 7 ‘Psychotherapeutic effects’ of estrogen substitution during the climacteric period.- 8 Double-blind studies on the effects of natural estrogens on postmenopausal women: a follow-up report.- 9 Considerations concerning the clinical treatment of the principal micturitional disturbances of the postmenopause.- 10 The urethral syndrome — role of estrogens in the therapy.- 11 Relationships of ovary, endometrium and vagina to estrogen therapy in the postmenopause.- 12 Prolactin in postmenopausal endometrial hyperplasia and adenocarcinoma.- 13 The prevention and treatment of endometrial pathology in postmenopausal women receiving exogenous estrogens.- 14 Treatment of patients at risk. Cross-over study between natural estrogens.- 15 Estrogen therapy preparatory to vaginal surgery in advanced menopause.- 16 The correction by estrogens of calcium disorders induced by estrogen-deficient states.- 17 Calcium metabolism in the postmenopause and sex steroid therapy: postmenopausal osteoporosis and sex steroids.- 18 Prevention and treatment of postmenopausal osteoporosis.- 19 The clinical epidemiology of breast and uterine cancer.- 20 Estrogens and endometrial cancer: a pathologist’s perspective.- 21 Steroid-induced changes in the endometrium of postmenopausal women.- 22 Mutagenicity and estrogens.- 23 Estrogens and endometrial cancer. A preliminary report.- 24 Exogenous estrogen therapy in the menopause: influence on mammary cancer risk.- 25 The effects of exogenous estrogen replacement on breast parenchymal patterns.- 26 Replacement therapy of the menopause and breast cancer.- 27 Estrogen and estrogen-progestogen compounds. Is there a risk for the development of endometrial and breast cancer in the perimenopausal woman?.- 28 Role of estrogens and progestogens in the etiology of breast and endometrial neoplasia.- Discussion.