The Mechanism of Chemical action of hCG

ISBN-13: 9783659866296 / Angielski / Miękka / 2016 / 336 str.

Sami Al-Mudhaffar

Opis

The concentration of intact human chorionic gonadotropin (hCG) and free subunit (hCG ) in sera and tissues of patients with gynecologic cancers was determined by radioimmunoassay. Intact hCG and free hCG levels were found to be elevated above the reference value (5mIU/ml) in sera of 50% of patients with epithelial ovarian cancer and in sera of 44% of patients with endometrial cancer. The sera intact hCG and free hCG levels were significantly higher in malignant then in non-malignant gynecologic tumors (P<0.05). Elevation intact hCG and free hCG above 5mIU/ml in tissues was found in 100% of patients with epithelial ovarian and endometrial cancers.The characteristics of the binding of 125I-hCG to hCG receptor in ovarian and uterine tumors homogenates were investigated using the radio receptor assay (RRA). Different factors affecting this binding were studied and the result showed that the maximum binding was achieved by using 500 and 700 µg protein of ovarian and uterine homogenate respectively, 17 and 4 Pmol of 125I-hCG concentration for ovarian and uterine tumors respectively, pH(7-7.4) for both tumors.

O autorze

In 1962 he moved to the University of Virginia Tech., USA, for advanced studies under a merit assistantship awarded by that university, culminating in a PhD (1967).He became Assistant Professor (1971), and full Professor of Biochemistry (1979) at the University of Baghdad, Iraqand become active member of Iraqi academy of science (almajma alilmi )