The Mast Cell: A Multifunctional Effector Cell

ISBN-13: 9783030241926 / Angielski / Miękka / 2020 / 112 str.

Domenico Ribatti

Spis treści

 

1.      Foreword

 

2.      Mast cell ontogeny

2.1. Background

2.2. First evidence of bone marrow origin

2.3. Development of mast cells along the myeloid pathway

2.4. Stem cell factor

2.5. Integrins and cell adhesion molecules

2.6. Chemokine receptors and interleukins

 

3.      Staining of mast cells

3.1.Background

3.2. Metachromasia

3.3. Alcian blue-safranin

3.4. The tyrosine kinase kit receptor

3.5. Tryptase and chymase

3.6. Other stainings

 

4.      Mast cells heterogeneity

4.1. Background

4.2.  Mast cells in thymus

4.3. Mast cells in duodenum

4.4. Mast cells in mammary gland

4.5. Other localizations

4.6. Mechanistic insights

 

5.      Mast cell biology and functions

5.1.Background

5.2.Mast cell derived secretory products

5.3.Mast cell immunological functions

5.4.Mast cell non-immunological functions

 

6.      Mast cells in arteriogenesis

6.1.Background

6.2.Factors involved in angiogenesis and arteriogenesis

6.3.Inflammatory cells in arteriogenesis

6.4.Mast cells in arteriogenesis

6.5.Perspectives

 

7.      Mast cells in primary systemic vasculitides

7.1.Background

7.2.Experimental evidence of the involvement of mast cells in vasculitides

7.3.Clinical evidence of the involvement of mast cells in vasculitides

7.4.Therapeutic perespectives

 

8.      Mast cells in blood-brain barrier alterations and neurodegenerative diseases

8.1.The blood-brain barrier

8.2.Mast cells in the brain

8.3.Mast cells in cerebral ischemia

8.4.Mast cells in multiple sclerosis

8.5.Mast cells in angiogenesis in diseases associated with blood brain barrier alterations

8.6.Perspectives

 

9.      Mast cells and basophils: a link between angiogenesis and inflammation in allergic diseases

9.1.General biology and mediators of mast cells and basophils

9.2.Mast cells and basophils in allergy

9.3.Mast cells and basophils in inflammation, angiogenesis and tissue remodeling

 

10.  Mast cells in tumor fate

10.1.              Tumor microenvironment

10.2.              Mast cells and tumor growth: pros and cons

 

11.  Mast cells in tumor angiogenesis and lymphoangiogenesis

11.1.              Mediators released by human mast cells involved in the angiogenic response

11.2.              The CAM assay in the study of mast cell-induced angiogenesis

11.3.              Mast cells in experimental tumor angiogenesis

11.4.              Mast cells and angiogenesis in solid tumors

11.5.              Mast cells and angiogenesis in haematological malignancies

11.6.              Mast cells in tumor lymphoangiogenesis

 

12.  Mast cells as therapeutic target in cancer

12.1.              Background

12.2.              Inhibition of of the SCF/kit axis

12.3.              Tyrosine kinase inhibitors

12.4.              Other molecules

12.5.              Perspectives

Index.

 

 

O autorze

The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications.

Blurb

This book covers the most important aspects of Mast Cell Biology. It enables the reader to immerse in the new aspects of Mast Cells biology, which are no longer seen as an immunological effector cell, but a multi-functional efector cell. One which have roles that expands beyond the immunological realm and shows deep implications in the pathophysiology of several human disorders as well as transforming into a very important and promising target for therapy development in cancer, neurodegerative disorders, angiogenesis, inflammation and allergy.

Across twelve chapter on Mast Cells Research, starting from the discovery and characterization of Mast Cells until the lastest findings and translational perspectives, the reader will get a complete view and a profound insight on the fundamental and applied aspects of Mast Cells Biology. The chapters are written in a clear and concise way in order to help navigating through complex biological scenarios.

The author, Domenico Ribatti, Full professor of the University of Bari, is an expert in the field of Mast Cells with more than 800 publications.