The Interleukins

ISBN-13: 9781468448405 / Angielski / Miękka / 2013 / 291 str.

Steven Gillis

Opis

Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor."

Spis treści

Receptors for T-Cell Growth Factor: Structure, Function, and Expression on Normal and Neoplastic Cells.- Toward the Molecular Biology of IL-2.- Interleukin-2 and the Regulation of Natural Killer Activity in Cultured Cell Populations.- Biochemical and Biological Properties of Interleukin-3: A Lymphokine Mediating the Differentation of a Lineage of Cells that Includes Prothymocytes and Mastlike Cells.- P-Cell Stimulating Factor: Biochemistry, Biology and Role in Oncogenesis.- Mast-Cell Growth Factor: Its Role in Mast-Cell Differentiation, Proliferation, and Maturation.- Soluble-Factor Induction of B-Cell Growth.- Role of Interleukin-1 in Human B-Cell Activation.- T-Cell Factors That Promote Cell Proliferation and Differentiation.- T-Cell-Replacing Factor and Its Acceptor Site on B Cells: Molecular Properties and Immunogenetic Aspects.- In Vivo Administration of Interleukin-2.