The Influence of Antibiotics on the Host-Parasite Relationship II

ISBN-13: 9783642707506 / Angielski / Miękka / 2011 / 298 str.

Dieter Adam; Helmut Hahn; Wolfgang Opferkuch

Opis

The Second International Symposium on "The Influence of Antibiotics on the Host Parasite Relationship" was held in Munich, F. R. G., from March 28 to 30,1985. The topics of the meeting dealt with the aspects of changes in bacterial metabolism and structure which occur under the influence of antibiotics, and with the effects of such changes on the antibacterial host resistance. The influence on pathogenicity factors, changes in the outer membrane of bacteria, as well as the influence on the individual components of the defence system were analysed in detail. In addition, these studies showed that antibiotics proved to be an excellent tool for the examination of bacterial physiology, so that, 50 years after the introduction of antibiotics, additional important knowledge can be gained about the effect of these substances on bacteria. Considering the observations reported, it appears justifiable to postulate that new antibiotics should be routinely tested with respect to their possible effects on antiinfectious resistance. Of course, a consensus will have to be found on which to base methods and criteria employ d. The symposium documented an increasing interest of microbiologists and clini cians for this field of research. It would not have been possible to organize it without the substantial support of the Paul Ehrlich Society as well as of Squibb-Von Heyden Pharma, Inc. Particular help concerning the organization has been given by Werner Kremer of Squibb-Von Heyden Pharma."

Spis treści

I. The Influence of Antibiotics on the Morphology and the Surface of Bacteria.- Effect of Subinhibitory Concentrations of Antibiotics on Surface Proteins of Neisseria gonorrhoeae and Neisseria meningitidis: Changes that Alter Attachment of Human Cells.- Discussion.- Interaction of Aminoglycosides and Ciprofloxacin with Bacterial Membranes.- Discussion.- The Influence of Ciprofloxacin on the Ultrastructure of Gram-negative and Gram-positive Bacteria.- Discussion.- Exposure of Protein Antigens and Reduction of Siderophore Production after growth of Gram-Negative Bacteria in Sub-Inhibitory Concentrations of Cephalosporins.- Discussion.- The Influence of ß-Lactam Antibiotics Including Monobactam on the outer and inner Membrane of E. coli.- Discussion.- Changes in outer Membrane Composition after Treatment of Proteus mirabilis with Antibiotics.- Discussion.- Weight and Morphology of Bacteria Exposed to Antibiotics.- Discussion.- II. The Influence of Antibiotics on Immunogenicity.- Immunogenicity of Bacteria Treated in vitro with Subinhibitory Concentrations of Antibiotics.- Discussion.- Influence of Subminimal Inhibitory Concentrations of Antibiotics on Antigen Expression and Metabolic Activity of Salmonella Species.- Discussion.- Influence of Ciprofloxacin on Specific Interactions on Listeria-specific T Cells with Antigen in vitro.- Discussion.- III. The Influence of Antibiotics on the Interaction of Bacteria with Host Defence Mechanisms.- a) Serum Bactericidal Activity.- Effects of Antibiotics on the Sensitivity of Proteus mirabilis to the Bactericidal Action of Normal Human Serum.- Discussion.- Imipenem Renders Serum Resistant Enterobacter aerogenes and Escherichia coli to Serum Sensitive Bacteria.- Discussion.- b) Phagocytosis.- Influence of Subinhibitory Concentrations of Clindamycin on the Phagocytosis of Staphylococcus aureus.- Discussion.- The Effect of Antibiotics on the Killing of E. Coli by Macrophages of the Cell Line P 388 D1.- Discussion.- Antibiotics and Polyelectrolytes Modulate Bacteriolysis and the Capacity of Bacteria to Trigger an Oxygen Burst in Neutrophils.- Discussion.- Chemiluminescence of Macrophages induced by Non-Opsonized E. coli treated with Subinhibitory Concentrations of ?-Lactam Antibiotics.- Discussion.- Indirect Antibiotic Effects on Granulocyte Migration and Phagocytosis.- Discussion.- Interactions between human Polymorphonuclear Neutrophils and Ampicillin treated Escherichia coli.- Discussion.- The Effect of Subinhibitory Concentrations of selected Antibiotics on Bacteria-Phagocyte Interactions.- Discussion.- The effect of subinhibitory concentrations of monobactams and bactericidal activity of macrophages.- Discussion.- IV. The Influence of Antibiotics on the Pathogenicity Factors and Virulence.- a) Adherence.- Effects of Antibiotics on Streptococcal Adherence: Release of Fibronectin-Lipoteichoic Acid Complexes from Group A Streptococci by Sublethal Concentrations of Penicillin.- Discussion.- Influence of Subinhibitory Concentrations of Antibiotics on Aggregation and Adherence of Streptococcus mutans.- Discussion.- b) Toxin Production and Virulence.- Clostridium Difficile Colonization of Infant Hamsters.- Discussion.- Gentamicin and Tobramycin selectively inhibit the secretion of Pseudomonas aeruginosa elastase.- Discussion.- Subinhibitory concentrations of antibiotics modulate amount of Shiga-like toxin produced by Escherichia coli.- Discussion.- Interference of ciprofloxacin with the expression of pathogenicity factors of Pseudomonas aeruginosa.- Discussion.- V. Miscellaneous.- In vivo Consequences of the Interaction between Antibiotic-damaged Pathogens and Host Animal Defences.- Discussion.- The Influence of Streptomycin on the Ecology of the Intestine and Resistance to Infection.- Discussion.- Protection of tracheal explants infected with Pseudomonas aeruginosa by subinhibitory concentrations of aminoglycosides.- Discussion.- Use of Lectins to Characterize Surface Alternations of ?-Lactam Resistant mutants of Pseudomonas aeruginosa.

O autorze

Herr Professor Helmut Hahn ist emeritiert und im Vorstand der Berliner Medizinischen Gesellschaft aktiv.