The Immunology of Cardiovascular Homeostasis and Pathology

ISBN-13: 9783319862071 / Angielski / Miękka / 2018 / 283 str.

Susanne Sattler; Teresa Kennedy-Lydon

Spis treści

Preface
Introduction
Section 1: The Immune system in tissue and organ homeostasis
Chapter 1: The Immune system beyond the fight against infection
Section 2: Immune functions and properties of resident cells in the heart and cardiovascular system
Chapter 2: Cardiomyocytes: Paying for the Tolls - The High Cost of the Innate Immune System for the Cardiac Myocyte
Chapter 3: Fibroblasts: Properties and immune function of cardiac fibroblasts
Chapter 4: Endothelial cells
Chapter 5: Pericytes
Chapter 6: Tissue-resident macrophages: The role of cardiac tissue macrophages in homeostasis and disease
Section 3: The immune system in cardiovascular pathology
Chapter 7: Atherosclerosis
Chapter 8: Immune mediated heart disease
Chapter 9: Vasculitis in the central nervous system
Chapter 10: Cardiac Autoimmunity: Myocarditis
Section 4: The immune system in repair and regeneration after myocardial infarct
Chapter 11: Lymphocytes at the heart of wound healing
Chapter 12: The innate immune system in cardiovascular repair and regeneration
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O autorze

Susanne Sattler, National Heart and Lung Institute, Imperial College London

Teresa Kennedy-Lydon, National Heart and Lung Institute, Imperial College London

Blurb

Cardiovascular immunology is a newly emerging research area, investigating the crosstalk between the cardiovascular and the immune system. This crosstalk is evident through (1) crucial immunological capacities and functions of cardiovascular cell types, including cardiomyocytes, fibroblasts, endothelial cells, pericytes and cardiac resident macrophages, (2) the impact of aberrant immune function on the development of cardiovascular disease such as atherosclerosis, direct and indirect immune-mediated heart disease and vasculitis, and (3) the crucial role of the immune system in cardiac repair and regeneration.

The Immunology of Cardiovascular Homeostasis and Pathology covers all these aspects of cardiovascular immunology, starting with homeostatic immunological functions of traditional cardiovascular cell types, and moving then to the role of the immune system in cardiovascular pathology and to recent research into targeting the immune system to boost cardiac healing and regeneration.