The Hunt for Foxp5: A Genomic Mystery Novel

ISBN-13: 9783319289601 / Angielski / Miękka / 2016 / 251 str.

David Deamer; Wallace Kaufman

Opis

Genetics professor Michelle Murphy loses her husband under mysterious circumstances and without warning, while their brilliant eight year old daughter Avalon, adopted in Kazakhstan, stubbornly believes she is a mutant. As if this were not enough she soon finds herself thrown into the middle of a quickly thickening plot, where the legacy of Genghis Khan meets the hunt for FOXP5, a genetic transcription factor that could herald the dawn of new human species. Initially caught helplessly between well-meaning fellow scientists, the government and more sinister agents, Michelle, with the help of a host of unlikely heroes, eventually takes control and finds the courage to confront the decision of whether to save human lives or humanity. The scientific and technical aspects underlying the plot - in particular aspects of FOX proteins, genetic mutations, viruses and cancer as well as the relation between intelligence and cortical complexity - are introduced and discussed by the authors in an extensive non-technical appendix.

Recenzje

"This is a fun read! ... The authors add genuine authenticity with their own thorough scientific research and personal knowledge of Kazakhstan - it's believable and a great combo: an intriguing international plot, an exotic location, well-drawn characters you care about and a mystery that keeps you intrigued and guessing from beginning to end. A good read for yourself or a great gift for a friend who appreciates well-written mysteries." (Deborah Wood, Amazon.com, February, 2017)

"This title by Wallace Kaufman and David Deamer, I would say, is the best I've ever read in terms of achieving a balance of the two. ... enjoyed the adventure, which hovered between adult and young adult in apparent audience level, and felt I was really gaining something from the science content - so a good thumbs up to Messrs Kaufman and Deamer." (Brian Clegg, Popular Science, popsciencebooks.blogspot.de, July, 2016)

Spis treści

Preface.- Part I: The Novel.- Part II: The Science behind the fiction.

O autorze

David Deamer is Research Professor of Biomolecular Engineering at the University of California (Santa Cruz). He recently published First Life: Discovering the Connections between Stars, Cells, and How Life Began (University of California Press, 2011). Deamer's primary research interest focuses on nucleic acid molecules as they are driven electrophoretically through a nanoscopic channel, or nanopore, embedded in a lipid-bilayer membrane. The presence of the polynucleotide in the channel affects the ionic conductance in a manner related to chain length, concentration and base sequence. This observation has considerable potential for characterizing DNA and RNA in microscopic volumes of nucleic acid solutions. In 2014, Oxford Nanopore Technology introduced the MinION, a portable nanopore sequencing instrument that is now undergoing testing by early users. These include NASA scientists who will send MinIONs to the International Space Station.

Wallace Kaufman is a science writer whose fiction, non-fiction, journalism, and poetry have appeared in major magazines and newspapers in the U.S., England, and Kazakhstan. He is a graduate of Duke University and he earned an M.Litt. from Oxford University. His research and reporting has taken him to Central and South America and to the arctic and Pacific coasts of Siberia. In Latin America he helped indigenous writers establish themselves and translated the first two books by Mayan writer Victor Montejo. In Kazakhstan he worked with Kazakhs on translations of their principal writers. His own translations of German, French and Spanish poetry and fiction have appeared in several magazines. His books include Invasive Plants: Guide to Identification and the Impacts and Control of Common North American Species, co-author with Dr. Sylvan Ramsey Kaufman, Stackpole Books, 2nd edition, 2013, Coming Out of the Woods, a memoir, Perseus Books, 2001, No Turning Back, Basic Books, 1994, Amazon, Gallery Books, Image Bank, 1991 and The Beaches Are Moving: The Drowning of America's Shoreline, Doubleday, 1979; Duke University Press 1984. Co-authored with Dr. Orrin Pilkey.

  

Blurb

Genetics professor Michelle Murphy loses her husband under mysterious circumstances and without warning, while their brilliant eight-year-old daughter Avalon, adopted in Kazakhstan, stubbornly believes she is a mutant.

As if this were not enough, she soon finds herself thrown into the middle of a quickly thickening plot, where the legacy of Genghis Khan meets the hunt for FOXP5, a genetic transcription factor that could herald the dawn of new human species.

Initially caught helplessly between well-meaning fellow scientists, the government, and more sinister agents, Michelle eventually takes control with the help of a host of unlikely heroes and finds the courage to confront the decision of whether to save human lives or humanity. The scientific and technical aspects underlying the plot – in particular aspects of FOX proteins, genetic mutations, viruses, and cancer as well as the relation between intelligence and cortical complexity – are introduced and discussed by the authors in an extensive, non-technical appendix.

 

Science writer Wallace Kaufman’s work has appeared in major magazines and newspapers in the U.S., England, and Kazakhstan. After Duke University he earned an M.Litt. from Oxford. His writing has taken him to Central and South America, to European Russia and the coasts of Siberia. He worked in most of Central Asia and served as resident adviser on housing and land reform in Kazakhstan. His books include Invasive Plants: Guide to Identification and the Impacts and Control of Common North American Species (2nd edition, 2013), Coming Out of the Woods -  A Memoir (2001), No Turning Back (1994), and The Beaches Are Moving: The Drowning of America's Shoreline, (1979/1983). 

 

David Deamer is a Research Professor of Biomolecular Engineering at the University of California, Santa Cruz. He recently published First Life: Discovering the Connections between Stars, Cells, and How Life Began (2011). Deamer's research concerns molecular self-assembly processes related to the origin and evolution of membrane structure. Over the past 25 years, he has been engaged in developing  nanoscopic pores in lipid bilayers as a way to sequence DNA. This work came to fruition in 2015 when the first portable nanopore sequencing device was successfully tested by early users.