The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume III: Metabolic and Peripheral Biomarkers

ISBN-13: 9789048182107 / Angielski / Miękka / 2010 / 213 str.

Ritsner, Michael

Opis

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances.§This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: Neuropsychological Endophenotypes and Biomarkers (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers , Metabolic and Peripheral Biomarkers and Molecular Genetic and Genomic Markers . The contributors are internationally and nationally recognized researchers and experts from 16 countries.§This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.

Spis treści

Foreword Contributors Part I. Possible Metabolic and Peripheral Biomarkers 1. Peripheral biomarkers in dementia and Alzheimers disease. Christian Humpel and Josef Marksteiner 2. S100B as a potential neurochemical biomarker in a variety of neurological, neuropsychiatric and neurosurgical disorders. Jon Sen 3. Can the cortisol to DHEA molar ratio be used as a peripheral biomarker for schizophrenia and mood disorders? Peter Gallagher and Michael S. Ritsner 4. Neuroactive steroid biomarkers of alcohol sensitivity and alcoholism risk. A. Leslie Morrow and Patrizia Porcu 5. Neuroendocrine markers of psychopathy. Andrea L. Glenn 6. Mitochondrial complex I as a possible peripheral biomarker for schizophrenia. Dorit Ben-Shachar 7. Peripheral biomarkers of excitotoxicity in neurological diseases. Lucio Tremolizzo, Gessica Sala and Carlo Ferrarese 8. Melatonin as a biological marker in schizophrenia. Armando L. Morera, Pedro Abreu-Gonzalez, Manuel Henry 9. Peripheral biological markers for mood disorders. Ghanshyam N. Pandey and Yogesh Dwivedi 10. The diagnosis of alcoholism through the identification of biochemical markers in hair. Nadia De Giovanni 11. Retinoic acid signalling in neuropsychiatric disease: possible markers and treatment agents. Sarah J. Bailey and Peter J. McCaffery 12. Abnormalities of inositol metabolism in lymphocytes as biomarkers for bipolar disorder. Galila Agam, Yuly Bersudsky and Robert H. Belmaker Afterword by Robert H. Belmaker Contents of Volumes 1, 2, and 4 Contributors of Volumes 1, 2, and 4 Index