The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes: Volume II: Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers

ISBN-13: 9781402098307 / Angielski / Twarda / 2009 / 243 str.

Michael S. Ritsner

Opis

Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer s disease, epilepsy, alcoholism, substance abuse and others are one of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: Neuropsychological Endophenotypes and Biomarkers (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers, Metabolic and Peripheral Biomarkers and Molecular Genetic and Genomic Markers . The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health. "

Spis treści

Foreword Contributors Neuroanatomical and Neuroimaging Findings 1. Role of imaging techniques in discerning neurobehavioral changes in ischemic, neurodegenerative and demyelinating disorders. Turi O. Dalaker, Mona K. Beyer, Milena Stosic and Robert Zivadinov 2. Neuroimaging biomarkers in Alzheimer's disease. Chong Mei Sian, Lim Wee Shiong 3. Towards a functional neuroanatomy of symptoms and cognitive deficits of schizophrenia. David Linden 4. Functional and structural endophenotypes in schizophrenia. Stephan Bender, Matthias Weisbrod and Franz Resch 5. Neuromorphometric measures as endophenotypes of schizophrenia spectrum disorders. Daniel Mamah, Deanna M. Barch, John G. Csernansky 6. Magnetic resonance imaging biomarkers in schizophrenia research. Heike Tost, Shabnam Hakimi and Andreas Meyer-Lindenberg 7. Neurostructural endophenotypes in autism spectrum disorder. Armin Raznahan, Jay N Giedd and Patrick F Bolton 8. Neuroimaging biomarkers for bipolar disorder across the lifespan. Nick C. Patel, Michael A. Cerullo, David E. Fleck, Jayasree J. Nandagopal, Caleb M. Adler, Stephen M. Strakowski and Melissa P. DelBello 9. Neuroimaging studies of pediatric obsessive-compulsive disorder: special emphasis on genetics and biomarkers. Frank P. MacMaster and David R. Rosenberg 10. Structural brain alterations in cannabis users: association with cognitive deficits and psychiatric symptoms. Nadia Solowij, Murat Yücel, Valentina Lorenzetti, and Dan I. Lubman Afterword by Robert H. Belmaker Contents of Volumes 1, 3, and 4 Contributors of Volumes 1, 3, and 4 Index