The Guide to Investigation of Mouse Pregnancy

ISBN-13: 9780123944450 / Angielski / Twarda / 2014 / 832 str.

Croy, B. Anne Yamada, Aureo T. Adamson, S. Lee

Opis

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research.

• Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications
• Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes
• Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation
• Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Recenzje

"The editors must be congratulated with this book, which will be extremely useful to all investigators who are focussing on this most popular animal model."--Placenta, November 28, 2014

"The text is clear and concise and contains something for beginning and expert investigators alike...This book will be a valued addition to the library of any pregnancy researcher who uses mice as their model organism."--Journal of the American Veterinary Medical Association, 15-Sep-14

Spis treści

Part I. Atlas of Figure Plates Part II. Basic Biology Part IIA. Estrus, Early Development, Implantation and Uterine Receptivity Part IIB. The Maternal-Fetal Interface  Part IIC. Parturition, Lactation, Postnatal Behaviors and Outcomes Part III. Protocols for Studies of the Placenta and Pregnancy in Mice Appendix 1. Reproductive Performance in Common Strains of Mice