The Genetics of Diabetes Mellitus

ISBN-13: 9783540076513 / Angielski / Miękka / 1976 / 250 str.

W. Creutzfeldt; J. Kabberling; J. V. Neel

Opis

On February 21 and 22, 1975, an International Workshop on the "Genetics of Diabetes Mellitus" was held in Gottingen, West-Germany. This workshop had been organized hy the Department of Medicine, University of Gottingen, and was generously sponsored by the Deutsche Forschungsgemeinschaft. Some forty geneticists and clinicians from Europe and N orth America, working in the field of diabetes both in man and laboratory animals, participated. The 25lectures presented at the workshop are now assembled for publication. Some of the animated discussion which followed the presentations has been included in the final papers by the speakers. Some lectures summarize the recent literature, others present data from recent research. Thus, a comprehensive and modem review of the theoretical and practical problems of diabetes are offered by this volume. related to the genetics The confusion about the mode of inheritance of diabetes mellitus during the last two decades can only be resolved by joint discussions between geneticists interested in diabetes and clinical diabetologists interested in genetics. Knowledge of modem genetics and of the heterogeneity of diabetes mellitus are necessary in order to disentangle the complex scene. Optimistically, the publication of this work on the genetics of diabetes will help to achieve this aim and to establish the concept of genetic heterogeneity of diabetes mellitus. The editors are grateful to Springer-Verlag, Heidelberg, for the prompt publication of these proceedings and to the Farbwerke Hoechst AG, Frankfurt (M), for their contribution to the printing costs."

Spis treści

1. Diabetes Mellitus — A Geneticist’s Nightmare.- 2. The Genetics of Diabetes Mellitus — A Review of Family Data.- 3. The Genetics of Diabetes Mellitus — A Review of Twin Studies.- 4. Unsolved and Unsolvable Problems in Studying the Genetics of Diabetes.- 5. Clinician’s View and Questions on the Genetics of Diabetes Mellitus.- 6. Etiological and Promoting Factors in the Pathogenesis of Diabetes Mellitus.- 7. Genetic Syndromes Associated with Glucose Intolerance.- 8. The Natural History of Idiopathic Diabetes Mellitus. Heterogeneity of Insulin Responses in Latent Diabetes.- 9. Genetic Heterogeneities within Idiopathic Diabetes.- 10. The Inheritance of Maturity-Onset Type Diabetes in Young People.- 11. A Possible Virus Etiology for Juvenile Diabetes.- 12. HLA, Autoimmunity and Insulin-Dependent Diabetes Mellitus.- 13. Environmental Factors and Genetic Interactions.- 14. Diabetes Mellitus and Impaired GlucoseTolerance in Diseases with Chromosomal Aberrations.- 15. Diabetes Mellitus and Hyperlipidemias.- 16. Genetic Syndromes Associated with Lipatrophic Diabetes.- 17. Hereditary Hyperglycemic Syndromes in Laboratory Rodents.- 18. Environmental Influences on the Manifestation of Diabetes Mellitus in Chinese Hamsters.- 19. Diabetes in the Offspring of Conjugal Diabetic Parents.- 20. Diabetes Mellitus in Identical Twins.- 21. Microangiopathy in Diabetics of Different Etiologies.- 22. Diabetic Complications in Concordant Identical Twins.- 23. Prospective Studies on Patients with Asymptomatic Diabetes.- 24. Problems in Genetic Counselling for Diabetes Mellitus.- 25. Towards a Better Understanding of the Genetic Basis of Diabetes Mellitus.