The Genetics of African Populations in Health and Disease

ISBN-13: 9781107072022 / Angielski / Twarda / 2019 / 348 str.

Muntaser Ibrahim; Charles Rotimi

Opis

Biomedical approaches increasingly work with human variation and this volume focuses on Africa, the most genetically diverse continent, and the birthplace of modern humans. It considers population structure and the genetic basis of common infectious and non-communicable diseases in historic and modern contexts, to shed light on human biology.

Recenzje

'The scope of the contributions varies widely, from studies of single diseases (e.g., breast cancer, visceral leishmaniasis) to broad surveys (e.g., orphan diseases of North Africa, evolution of disease resistance). The first and final essays review the state and development of genetics research and medicine in Africa. Common themes include public health infrastructure, transition from agrarian to urban lifestyles, pharmacogenomics, genetic diversity, and the dearth of research on African populations.' R. M. Denome, Choice

Spis treści

1. Reflections on conceptualizing Africa for biological studies with a historical component: a small essay Shomarka Omar Y. Keita; 2. History and genetics in Africa: multidisciplinary efforts Shomarka Omar Y. Keita and Muntaser E. Ibrahim; 3. Disease, selection, and evolution in the African landscape Muntaser Ibrahim and Endashaw Bekele; 4. Genetic susceptibility to visceral leishmaniasis Hiba S. Mohamed, Muntaser E. Ibrahim and Jenefer M. Blackwell; 5. Genetics of infection in Sub-Saharan Africa: what can the study of Mendelian immunodeficiency disorders contribute? Melanie Newport; 6. Pharmacogenomics and infectious diseases in Africa: an evolutionary perspective Jennifer L. Baker, Daniel Shriner, Amy R. Bentley and Charles N. Rotimi; 7. A glimpse into pharmacogenomics in Africa Collet Dandara and Alice Matimba; 8. Genomics of cardiometabolic disorders in Sub-Saharan Africa Sally N. Adebamowo, Fasil Tekola-Ayele, Adebowale A. Adeyemo and Charles N. Rotimi; 9. Breast cancer in African populations Konduru S. Sastry and Lotfi Chouchane; 10. Socio-biological transition and cancer: prospects for Africa Sulma Mahmoud, Khalid O. Alfarouk, Ahmed M. Elhassan, Kamal Hamad and Muntaser E. Ibrahim; 11. The genetic epidemiology of orphan diseases in North Africa Lilia Romdhane, Olfa Messaoud, Rym Kefi, Afaf Tiar, Ahlem Amouri, Mourad Mokni, Neji Tebib, Mohamed Zghal, Abdelhamid Barakat, Ahmed Houmeida, Mariem Bozguiya, Mohamed Othman, Ghada El Qameh and Sonia Abdelhak; 12. Birth defects and genetic disease in Sub-Saharan Africa Ambroise Wonkam; 13. Neurogenetic disorders in Africa: hereditary spastic paraplegia: a case study Liena E. O. Elsayed, Ammar E. M. Ahmed and Giovanni Stevanin.