The Genetics and Development of Scoliosis

ISBN-13: 9781489982964 / Angielski / Miękka / 2014 / 218 str.

Kenro Kusumi;Sally L Dunwoodie

Opis

Scoliosis is a heterogeneous group of spinal curvature disorders that are frequently encountered by health professionals (estimated to affect 2-3% of the population). Patients are concerned about prognosis, associated health conditions and recurrent risks. Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine. Recent developments in clinical and molecular genetic studies of these disorders are also discussed.

Spis treści

Genetic Regulation of Somite and Early Spinal Patterning.- Development and Functional Anatomy of the Spine.- Environmental Factors and Axial Skeletal Dysmorphogenesis.- Overview and Comparison of Idiopathic, Neuromuscular, and Congenital Forms of Scoliosis.- Abnormal Vertebral Segmentation (or Segmentation Defects of the Vertebrae) and the Spondylocostal Dysostoses.- Spondylothoracic Dysostosis in Puerto Rico.- Progress in Understanding Genetic Contributions in Syndromic and Non-Syndromic Disorders Associated with Congenital, Neuromuscular, and Idiopathic Scoliosis.- Genetics and Functional Pathology of Idiopathic Scoliosis.- Current Understanding of Genetic Factors in Idiopathic Scoliosis.- Conclusion: Trends and Predictions for Genetic and Developmental Biological Research on Scoliosis.

O autorze

Kenro Kusumi, Ph.D., is an Associate Professor in the School of Life Sciences at Arizona State University and is a founding faculty member at the new University of Arizona College of Medicine-Phoenix in partnership with Arizona State University. Dr. Kusumi’s current research focuses on early spinal development, axial musculoskeletal regeneration, and their applications to genetic studies of scoliosis and other musculoskeletal disorders.

Sally L. Dunwoodie, Ph.D., is an Associate Professor at the University of New South Wales and Laboratory Head in the Developmental Biology Division at the Victor Chang Cardiac Research Institute in Sydney. Dr Dunwoodie's research focuses on development of the spine, heart, kidney and placenta in mouse, and their relevance to the molecular basis of congenital abnormalities.

Blurb

The Genetics and Development of Scoliosis

edited by Kenro Kusumi, Ph.D.

Table of Contents:

Genetic Regulation of Somite and Early Spinal Patterning Kenro Kusumi, Ph.D., Walter Eckalbar, Olivier Pourquie, Ph.D.

Development and Functional Anatomy of the Spine J. Alan Rawls, PhD and Rebecca E. Fisher, PhD

Environmental Factors and Axial Skeletal Dysmorphogenesis Peter G. Alexander, Ph.D. and Rocky Tuan, Ph.D.

Overview and Comparison of Idiopathic, Neuromuscular, and Congenital Forms of Scoliosis Benjamin Alman, M.D.

Abnormal Vertebral Segmentation (or Segmentation Defects of the Vertebrae) and the Spondylocostal Dysostoses Peter D. Turnpenny, M.B.Ch.B.

Spondylothoracic Dysostosis in Puerto Rico Alberto Santiago Cornier, M.D., Ph.D.

Progress in Understanding Genetic Contributions in Syndromic and Non-Syndromic Disorders Associated with Congenital, Neuromuscular, and Idiopathic Scoliosis Philip F. Giampietro, M.D., Ph.D.

Genetics and Functional Pathology of Idiopathic Scoliosis Nancy Hadley Miller, M.D.

Current Understanding of Genetic Factors in Idiopathic Scoliosis Carol A. Wise, Ph.D. and Swarkar Sharma, Ph.D.

Conclusion: Trends and Predictions for Genetic and Developmental Biological Research on Scoliosis Kenro Kusumi, Ph.D.