The GABA Receptors

ISBN-13: 9781588298133 / Angielski / Twarda / 2007 / 336 str.

Hanns Mohler; S. J. Enna

Opis

This volume is the third edition of a monograph series that was first published in 1983. The demand for this work is a testament to the impact of studies on -aminobutyric acid (GABA) receptors on the basic understanding of synaptic transmission and on defining the clinical importance of the neurotransmitter system. Chronicled in The GABA Receptors, Third Edition, are the advances made in understanding the molecular and pharmacological properties of GABA A and GABA receptors since the topic was last reviewed in 1996. Particular B emphasis is placed on describing the assembly, structure, and function of GABA B sites, the first heterodimeric G protein-coupled receptors identified in vivo. In addition, there are reports dealing with the subunit composition, trafficking, and pharmacological selectivity of GABA receptors. Aside from providing A insights into the fundamental properties of ligand-gated ion channels and second messenger systems, the findings detailed in this work point the way for developing novel therapeutics capable of more selectively manipulating these transmitter sites.

Spis treści

TABLE OF CONTENTS THE GABA RECEPTORS 3rd EDITION S.J. Enna and Hanns Mohler, eds. Chapter 1: THE GABA RECEPTORS. S.J. Enna [NOTE: Please do NOT use 'Sam' or 'Salvatore' - only 'S.J' should appear anywhere it is listed in the book.] Chapter 2: FUNCTIONAL RELEVANCE OF GABAA RECEPTOR SUBTYPES. H. Mohler and U. Rudolph Chapter 3: TRAFFICKING OF POSTSYNAPTIC GABAA RECEPTORS BY RECEPTOR-ASSOCIATED PROTEINS. X. Yuan and B. Luscher. Chapter 4: SUBUNIT COMPOSITION AND STRUCTURE OF GABAA RECEPTOR SUBTYPES. W. Sieghart Chapter 5: DIFFERENTIAL ACTIVATION OF GABAA RECEPTOR SUBTYPES. M. Farrant Chapter 6: GABAA RECEPTOR MUTATIONS ASSOCIATED WITH IDIOPATHIC GENERALIZED EPILEPSIES AND FEBRILE SEIZURES. R.L. Macdonald, J-Q. Kang, M.J. Gallagher, H-J. Feng. Chapter 7: ABUSE AND DEPENDENCE LIABILITY OF GABAA RECEPTOR MODULATORS: ANTECEDENTS AND PHARMACOLOGY. J.K. Rowlett, A.N. Duke, D.M. Platt Chapter 8: MECHANISMS OF GABAA AND GABAB RECEPTOR GENE EXPRESSION. D.H. Farb, J.L. Steiger, S.C. Martin, M.C. Gravielle, T.T. Gibbs, S.J. Russek Chapter 9: CHEMISTRY OF GABA-B MODULATORS. W. Froestl, N.G. Cooke, S.J. Mickel Chapter 10: THE UNUSUAL FUNCTIONING OF THE GABAB RECEPTOR HETERODIMER: AN OLD RECEPTOR TEACHING NEW FUNCTIONAL TRICKS. A. Couve, S.J. Moss, M.N. Pangalos Chapter 11: CHARACTERISTICS OF GABA-B RECEPTOR KNOCK-OUT MICE. J. Tiao, B. Bettler Chapter 12: GABAB RECEPTOR AS A POTENTIAL THERAPEUTIC TARGET. N.G. Bowery End of Table of Contents, THE GABA RECEPTORS, 3rd Edition, Humana Press