The Future of Aging: Pathways to Human Life Extension

ISBN-13: 9789048139989 / Twarda / 2010 / 866 str.

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Opis

Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Spis treści

Part 1: Introduction and Orientation; Chapter 1 Bridges to Life; Ray Kurzweil, Kurzweil Technologies, Inc. Wellesley, MA, and Terry Grossman, M.D., Frontier Medical Institute, Denver, CO; Chapter 2 Analyzing Predictions: An Anthropological View of Anti-Aging Futures; Courtney Everts Mykytyn, Ph.D., Department of Anthropology, University of Southern California, Los Angeles, CA, USA; Chapter 3 Towards Naturalistic Transcendence: The Value of Life and Life Extension to Persons as Conative Processes; Steven Horrobin, Ph.D., College of Medicine, University of Edinburgh, Scotland, UK; Chapter 4 The Ethical Basis for Using Human Embryonic Stem Cells in the Treatment of Aging; L. Stephen Coles, M.D., Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA; Chapter 5 Evolutionary Origins of Aging, Joshua Mitteldorf, Ph.D., Dept of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ Chapter 6 Precedents for the Biological Control of Aging: Experimental Postponement, Prevention, and Reversal of Aging Processes; Gregory M. Fahy, Ph.D., Intervene Biomedical, Norco, CA, USA; Part 2: The Future of Aging Chapter 7 An Approach to Extending Healthspan and Lifespan Today; Chris Heward, Ph.D.*, President, Kronos Science Laboratory, Phoenix, AZ, USA; *Deceased Chapter 8 Near-Term Prospects for Amelioration of Cardiovascular Aging, Roger Yu, M.D., Beth Israel Deaconess Medical Center, Boston, MA 02215, and Mohammad Navab, Ph.D., David Geffen School of Medicine, UCLA, Los Angeles, CA, USA ; Chapter 9 Near Term Prospects for Broad Spectrum Amelioration of Cancer; Zheng Cui, Ph.D., Wake Forest University School of Medicine, inston-Salem, NC, USA; Chapter 10 Small Molecule Modulators of Sirtuin Activity; Francisco J. Alcain, Ph.D., Robin K. Minor, Ph.D., Jose M. Villalba, Ph.D., Departamento de Biología Celular, Fisiología e Inmunología, Universidad de Córdoba, Córdoba, Spain, and Rafael de Cabo, Ph.D.,Laboratory of Experimental Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA; Chapter 11 Evolutionary Nutrigenomics; Michael Rose, Ph.D., Anthony D. Long, Ph.D., Laurence D. Mueller, Ph.D.,Cristina L. Rizza, Ph.D., Kennedy C. Matsagas, Ph.D.,Lee F. Greer, Ph.D., and Bryant Villeponteau, Ph.D.Genescient, LLC, Irvine, CA, USA; Chapter 12 Biological Effects of Calorie Restriction:Implications for Modification of Human Aging; Stephen R. Spindler, Ph.D., Department of Biochemistry,University of California at Riverside, Riverside, CA, USA; Chapter 13 Calibrating Notch/TGF-ß Signaling for Youthful, Healthy Tissue Maintenance and Repair; Morgan E. Carlson, Ph.D. and Irina M. Conboy, Ph.D., Department of Bioengineering, University of California, Berkeley, CA, USA; Chapter 14 Embryonic Stem Cells:Prospects of Regenerative Medicinefor the Treatment of Human Aging; Mike West, Ph.D., Chief Scientific Officer, BioTime, Inc., and Embryome Sciences, Inc., Alameda, CA, USA, and Adjunct Professor, University of California at Berkeley, Berkeley, CA, USA Chapter 15 Maintenance and Restoration of Immune System Function; Richard Aspinall, Ph.D., and Wayne Mitchell, Ph.D., School of Medicine, Division of Investigative Science,Imperial College London, London, UK Chapter 16 Mitochondrial Manipulation as a Treatment for Aging; Rafal Smigrodzki, M.D., and Francisco R. Portell, B.S., Gencia, Inc., Charlottesville, VA, USA; Chapter 17 Life Extension by Tissue and Organ Replacement; Anthony Atala, M.D., Director, Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA; Chapter 18 Telomeres and the Arithmetic of Human Longevity; Abraham Aviv, M.D., and John D. Bogden, Ph.D., The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ, USA; Chapter 19 Repairing Extracellular Aging and Glycation; John Furber, C.E.O.,