The Flaviviruses: Structure, Replication and Evolution: Volume 59

ISBN-13: 9780120398591 / Angielski / Twarda / 2003 / 369 str.

Karl Maramorosch; Aaron J. Shatkin; Frederick A. Murphy

Opis

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Structure, Replication and Evolution is the first volume of The Flaviviruses and presents the latest research covering the conceptual advances on aspects such as the characterization of virus structure, cellular receptors, mechanisms of virus entry, host and viral components of the RNA replicase.

• Includes new, detailed information on the evolution, viral structure and replication of the Flavivirus family
• The only complete reference book on a major virus family
• Descibes the technologies that have contributed to our current knowledge about Flaviviruses
• Identifies the major problems faced in understanding the virus-host interactions that result in disease

Recenzje

"...the chapters are well written, and the editors have ensured continuity of a high standard of writing throughout the set...Given the wealth of information, with contributions by over 60 authors, The Flavaviruses, really is an essential series of books that belongs on every arbovirologists' bookshelf." --Stephen Higgs, Ph.D., University of Texas Medical Branch, U.S., (2004)

Spis treści

Taxonomy of the virus family Flaviviridae
Structure and replication
Molecular Biology of the Flaviviruses
Flavivirus Structure and Membrane Fusion
Kunjin RNA replication and applications of Kunjin replicons
Antigenic structure of flavivirus Proteins
5' and 3' non-coding regions in flavivirus RNA
Manipulation of Cell Surface Macromolecules by Flaviviruses
Flavivirus evolution
Origins, Evolution and vecto/host cp-adaptations within the genus Flavivirus
Microevolution and virulence of dengue viruses