The Etiology of Atopic Dermatitis

ISBN-13: 9781447165446 / Angielski / Twarda / 2015 / 117 str.

Herbert B. Allen

Opis

This book will present completely new, unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. Dermatologists and pediatricians treat eczema exceedingly well and this is ordinarily accomplished with corticosteroid containing topicals. However, after treatment, it is intriguing that aggressive moisturization and cautious bathing will in most instances prevent future flares of the disease, even though it is precipitated by bacteria and their biofilms. Diseases where eczema has been found with a completely unrelated disorder have shown occluded sweat ducts on histopathologic examination. These include Meyerson's nevus which has a nevus and eczema in the same biopsy and Doucas Kapetanakis-type of pigmented purpuric dermatosis that shows occluded sweat ducts along with the capillaritis.

Recenzje

"The purpose is to present the biofilm bacterial occlusion theory as the inciting inflammatory immune event leading to eczema. The audience is all primary physicians and dermatologists." (Patricia Wong, Doody's Book Reviews, November, 2015)

Spis treści

Clinical presentations.- Microbiology.- Pathology.- Immunology.- Genetics.- Physiology.- Treatment.- Diseases in which eczema is a secondary component (Meyerson’s nevus and Doucas Kapetanakis pigmented purpuric dermatosis).- Diseases with occluded sweat ducts other than eczema (tinea pedis, axillary granular parakeratosis, seborrheic dermatitis).- The Story of Eczema in Pictures.- Epilogue: A comparison of psoriasis and eczema: both caused by bacteria, but neither an infection.

O autorze

Dr. Allen is a graduate of Johns Hopkins University School of Medicine. He has served on the boards of the American Society of Dermatology and the American College of Physicians and has published over 40 scientific articles in the fields of dermatology and dermatopathology. For the past ten years, he has been the Professor and Chair of the Department of Dermatology of Drexel University College of Medicine. Dr. Herbert B. Allen’s specialties include dermatology and dermatopathology, skin pathology and fungal infections and is board-certified with the American Board of Dermatology and the American Board of Pathology.

Blurb

Atopic dermatitis has been called “the itch that rashes”, and this book reveals what causes the “itch”. It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the “itching” and inflammation in this disease.

The Etiology ofAtopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.